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39976 Adgf-A

39976

Adgf-A

Adenosine deaminase-related growth factor A

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition Adenosine deaminase-related growth factor A

研究结论

Date Results Publications
2020-05-16 10:56:00 screen identified Adenosine Receptor (AdoR) as a top candidate required for intestinal stem cell (ISC) self-renewal and proliferation in the Drosophila midgut. Down-regulation of adenosine deaminase-related growth factor A (Adgf-A) from enterocytes is necessary for extracellular adenosine to activate AdoR and induce ISC overproliferation and Adgf-A activity decreases following tissue damage. 31852821
2018-07-28 11:03:00 Low ADGF-A expression is associated with increase in resistance to S. pneumoniae 29702691
2011-02-26 11:19:00 The effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A), was studied. 20940317
2010-01-21 00:00:00 findings show that a null mutation in ADGF-A leads to dramatically increased levels of adenosine & deoxyadenosine in the larval hemolymph; this increase leads to larval death associated with the disintegration of fat body & development of melanotic tumors 15907156

名称对应

Type IDs
Synonymous ADGDF-A, ADGF-A, Adgf-a, AdgfA, CG5992, Dmel\CG5992, adgf-a, adgfa
Gene
UniProtKB-ID: Q9VVK5_DROME
UniprotKB: Q9VVK5
UniParc: UPI000007BBE8
EMBL: AY058655, AE014296, AF337554
EnsemblGenome: FBgn0036752
KO: dme:Dmel_CG5992
Nucleutide sequences
EMBL-CDS: AAF49306.1, AAS64976.1, AAL13884.1, AAL40913.1
Gene_ORFName: CG5992, Dmel_CG5992
EnsemblGenome_TRS: FBtr0075191, FBtr0075190
Protein sequencees
EnsemblGenome_PRO: FBpp0074955, FBpp0089360
RefSeq: NP_524130.1, NP_996119.1
Others
UniRef100: UniRef100_Q9VVK5
UniRef90: UniRef90_Q9VVK5
UniRef50: UniRef50_Q9VVK5
UniGene: Dm.1714

全选

研究热度
发表文献
研究结论
热点单位
排名 科研单位 文献
1

University of California

6
2

Institute of Molecular Biotechnology of the Austrian Academy of Sciences

2
3

University of California Los Angeles

2
4

Howard Hughes Medical Institute

2
5

University of South Bohemia

2
热点人员
排名 研究人员 文献
1

Tomas Dolezal

7
2

Susan E Celniker

6
3

Michal Zurovec

6
4

Gerald M Rubin

5
5

Gary H Karpen

4
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