| Type | Description |
|---|---|
| Definition | LIM domain kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:26:00 | NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation. | 31695759 |
| 2020-07-11 10:05:00 | It has been found that LIMK1/LIMK2 is critical for GPER activation-induced breast cancer cell migration. | 31277940 |
| 2020-06-20 12:07:00 | LIMK1and LIMK2 expression status is associated with glioblastoma (GBM) grade and poor prognosis. Simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells. LIMK1/2 functionally regulated cell invasiveness, in part, by disrupting polarized cell motility under confinement and cell chemotaxis. | 31641031 |
| 2019-06-08 12:34:00 | LIM domain kinase 2 isoform LIMK2-1 (LIMK2-1) has a protein phosphatase 1 (PP1) inhibitory domain at its C-terminus which its two isoenzymes LIMK2a and LIMK2b do not. | 30373762 |
| 2019-06-08 11:08:00 | Analysis localized LIMK2 SNP rs2073859 (G-to-A allele) within the microRNA-135a binding region and revealed lower LIMK2 G allele expression. The frequency of A genotypes was higher in the bladder cancer (BC) group than normal controls and correlated with risks of higher grade and stage BC. LIMK2 may function as an oncogene in human BC, while allele-specific regulation by microRNA-135a may influence disease risk. | 30006972 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
LIMK2_HUMAN,
A0A024R1H6_HUMAN,
A0A024R1M2_HUMAN
UniprotKB:
P53671,
A0A024R1H6,
A0A024R1M2
UniParc:
UPI0000169F37,
UPI00000703D1,
UPI00000534BD
EMBL:
AK291640,
CR456513,
BC013051,
D45906,
AC002073,
D85527,
AL117466,
CH471095
Ensembl:
ENSG00000182541
KO:
hsa:3985
|
| Nucleutide sequences |
EMBL-CDS:
EAW59958.1,
CAG30399.1,
CAB55941.1,
AAH13051.1,
EAW59954.1,
AAB54056.1,
AAB54055.1,
BAF84329.1,
BAA08312.1,
EAW59956.1,
BAA12827.1,
EAW59955.1,
EAW59959.1
Gene_ORFName:
hCG_2010534,
hCG_2010534
Ensembl_TRS:
ENST00000331728,
ENST00000333611,
ENST00000340552
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000332687,
ENSP00000330470,
ENSP00000339916
RefSeq:
NP_005560.1,
NP_057952.1,
NP_001026971.1
|
| Others |
UniRef100:
UniRef100_P53671,
UniRef100_A0A024R1M2
UniRef90:
UniRef90_H2R706,
UniRef90_P53671
UniRef50:
UniRef50_P53671
UniGene:
Hs.474596
CCDS:
CCDS13892.1,
CCDS33637.1,
CCDS13891.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员