| Type | Description |
|---|---|
| Definition | notum |
| Date | Results | Publications |
|---|---|---|
| 2017-10-28 11:15:00 | Notum normally functions to coordinate synaptic structural and functional differentiation via negative regulation of Wg trans-synaptic signaling in the extracellular synaptomatrix. | 28860114 |
| 2015-04-11 10:57:00 | Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor; structural analyses reveal glycosaminoglycan binding sites on Notum, which probably help Notum to co-localize with Wnt proteins | 25731175 |
| 2012-10-20 10:20:00 | Hydrolysis of the Dally-GPI by Notum provides a switch from low to high level signalling by promoting internalisation of the Hh-Patched ligand-receptor complex. | 22872085 |
| 2011-12-31 10:03:00 | notum can cleave mammalian glypticans and GPI-anchored proteins from the cell surface. | 17967162 |
| 2010-05-10 11:38:00 | the long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum | 20412775 |
| Type | IDs |
|---|---|
| Synonymous | CG13076, Dmel\CG13076, Not, Nt, Wf, anon-WO0118547.482, anon-WO03062410.10, anon-WO03062410.8, l(3)72CDf, l(3)72Da, notum, ntm, wf |
| Gene |
UniProtKB-ID:
NOTUM_DROME
UniprotKB:
Q9VUX3
UniParc:
UPI000007B808
EMBL:
AJ457833,
AE014296,
AY078993
EnsemblGenome:
FBgn0044028
KO:
dme:Dmel_CG13076
|
| Nucleutide sequences |
EMBL-CDS:
AAL85497.1,
AAF49550.3,
CAD29885.1
Gene_ORFName:
CG13076
EnsemblGenome_TRS:
FBtr0075435
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0075193
RefSeq:
NP_730096.2
|
| Others |
UniRef100:
UniRef100_Q9VUX3
UniRef90:
UniRef90_Q9VUX3
UniRef50:
UniRef50_Q9VUX3
UniGene:
Dm.12824
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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