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39750 mib1

39750

mib1

mind bomb 1

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition mind bomb 1

研究结论

Date Results Publications
2018-06-23 10:47:00 The authors found that Dl requires ubi for its full function, but can also signal in two ubi-independent modes, one dependent and one independent of Neur. Their analysis suggests that one important role of Dl protein ubiquitination by Mib1 is their release from cis-inhibitory interactions with Notch, enabling them to trans-activate Notch on adjacent cells. 28960177
2016-10-22 12:17:00 While deficient Mib1 signaling leads to overgrowth of the NMJ, ubiquitous overexpression of Mib1 results in a reduction in the number of presynaptic motor neuron boutons and branches 26596173
2012-02-11 10:58:00 The ubiquitylation of Delta by both Neuralized and Mindbomb1 was detected, with the two enzymes using distinct docking sites and having different acceptor lysine preferences. 22162135
2010-01-21 00:00:00 Simultaneous absence of neuralized and mib1 completely abolishes Notch signaling in both lateral inhibition (generating single neural precursors from a field of equipotent cells)and wing dorsoventral boundary formation. 16093323
2010-01-21 00:00:00 both Dmib and Epsin are required in these cells for some of the endocytic events that internalize DSL ligands 15930117

名称对应

Type IDs
Synonymous CG5841, D-mib, D-mib1, Dmel\CG5841, Dmib, MIB1, Mib, Mib1, dmib1, l(3)72CDa, l(3)72Db, mib, mib1/2, mind-bomb
Gene
UniProtKB-ID: MIB_DROME, M9PI73_DROME
UniprotKB: Q9VUX2, M9PI73
UniParc: UPI0000081AD7, UPI0002941FBF
EMBL: AY118647, AE014296
EnsemblGenome: FBgn0263601
KO: dme:Dmel_CG5841
Nucleutide sequences
EMBL-CDS: AAF49551.3, AAM50016.1, AGB94606.1
Gene_ORFName: CG5841, CG5841, Dmel_CG5841
EnsemblGenome_TRS: FBtr0075520, FBtr0333578
Protein sequencees
EnsemblGenome_PRO: FBpp0075275, FBpp0305755
RefSeq: NP_001261913.1, NP_648826.2
Others
UniRef100: UniRef100_M9PI73, UniRef100_Q9VUX2
UniRef90: UniRef90_Q9VUX2
UniRef50: UniRef50_Q9VUX2
UniGene: Dm.10758

全选

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