| Type | Description |
|---|---|
| Definition | ADAM metallopeptidase domain 17 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-16 11:05:00 | these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy | 26724939 |
| 2016-07-30 10:30:00 | ADAM17 was involved in porcine CD16 shedding in porcine reproductive and respiratory syndrome virus-infected pigs. | 26653711 |
| 2015-01-24 11:49:00 | Overexpression of ADAM17 induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection. | 24965453 |
| 2014-05-03 10:36:00 | activation of TACE/ADAM17 via a c-Src-dependent manner mediates proteolytic activation of the EGF-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes | 24424050 |
| 2013-09-21 12:39:00 | Data indicate that TNF-alpha stimulates Rac, ADAM17/TACE, and RhoA through the guanine nucleotide exchange factor (GEF)-H1. | 23389627 |
| Type | IDs |
|---|---|
| Synonymous | TACE |
| Gene |
UniProtKB-ID:
A5A749_PIG
UniprotKB:
A5A749
UniParc:
UPI000151DC7C
EMBL:
AB271919
KO:
ssc:397343
|
| Nucleutide sequences |
EMBL-CDS:
BAF62294.1
|
| Protein sequencees |
RefSeq:
NP_001093396.1,
XP_020941513.1,
XP_020941514.1,
XP_020941512.1
|
| Others |
UniRef100:
UniRef100_A5A749
UniRef90:
UniRef90_P78536
UniRef50:
UniRef50_P78536
UniGene:
Ssc.19668
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 26724939 |
Immunol. Res. Ren Li , Longjun Guo , Weihong Gu , Xiaolei Luo , Jian Zhang , Yunfei Xu , Zhijun Tian , Li Feng , Yue Wang |
2016-06-01 | - |
| 26653711 |
J. Gen. Virol. Weihong Gu , Longjun Guo , Ren Li , Junwei Niu , Xiaolei Luo , Jian Zhang , Yunfei Xu , Zhijun Tian , Li Feng , Yue Wang |
2016-03-01 | - |
| 24965453 |
J. Virol. Longjun Guo , Junwei Niu , Haidong Yu , Weihong Gu , Ren Li , Xiaolei Luo , Mingming Huang , Zhijun Tian , Li Feng , Yue Wang |
2014-09-01 |
CD163,
ADAM17
|
| 24424050 |
Endocrinology Yasuhisa Yamashita , Minako Okamoto , Maki Ikeda , Asako Okamoto , Masatoshi Sakai , Yosuke Gunji , Ryo Nishimura , Mitsugu Hishinuma , Masayuki Shimada |
2014-03-01 |
ADAM17
|
| 23389627 |
Mol. Biol. Cell Faiza Waheed , Qinghong Dan , Yasaman Amoozadeh , Yuqian Zhang , Susumu Tanimura , Pam Speight , András Kapus , Katalin Szászi |
2013-04-01 |
ARHGEF2,
RAC3,
RHOA,
ADAM17
|
| 20168049 |
J. Reprod. Dev. Yasuhisa Yamashita , Ikko Kawashima , Yosuke Gunji , Mitsugu Hishinuma , Masayuki Shimada |
2010-06-01 | - |
| 17145712 |
Nucleic Acids Res. Hirohide Uenishi , Tomoko Eguchi-Ogawa , Hiroki Shinkai , Naohiko Okumura , Kohei Suzuki , Daisuke Toki , Noriyuki Hamasima , Takashi Awata |
2007-01-01 |
SPARCL1,
SLA-3,
DYNC1H1,
SLA-1,
P4HA1,
DNMT3A,
CPE,
TNFRSF1B,
SLA-DQB1,
CD14,
APOBEC3F,
PDE4B,
KCND3,
KCNIP2,
UIMC1,
C9,
C8A,
C8G,
SEPP1,
LOC100037968,
SLC7A7,
PET100,
TOMM7,
NDUFC1,
SLIRP,
LOC100037988,
COX6C,
COX7C,
NDUFV2,
PSMB7,
RPL10A,
RPL14,
RPL27,
RPS21,
TMSB10,
ATPIF1,
RCHY1,
CD1E,
SEP15,
CCL11,
CD72,
COX6B,
RPL4,
EIF4E,
LGALS3,
SNRPE,
ZFAND5,
SDHD,
C5AR1,
ABCG8,
CYB561,
GNAS,
RBM39,
BRCA1,
KRT2,
HPS4,
BLOC1S5,
BLOC1S6,
PNPLA3,
SRGN,
SPTAN1,
BIRC6,
HPS5,
AMPD1,
MMP12,
MYOT,
COL6A3,
EIF4E2,
PPP2R5A,
IFIH1,
EIF4A2,
EIF4A1,
SQLE,
CYP39A1,
ALG2,
BPIFB2,
BPIFB5,
CYP4F2,
SLC44A4,
DXO,
NIFK,
CD1D,
SNCG,
LNPEP,
MUC13,
COPS5,
SIRT2,
SIRT3,
RBM38,
ANGPTL2,
STC2,
AQP4,
LASS6,
CD302,
CYP3A46,
KRT18,
PEX6,
CNPY3,
MEA1
|
| 14681463 |
Nucleic Acids Res. Hirohide Uenishi , Tomoko Eguchi , Kohei Suzuki , Tetsuya Sawazaki , Daisuke Toki , Hiroki Shinkai , Naohiko Okumura , Noriyuki Hamasima , Takashi Awata |
2004-01-01 |
PIK3R6,
DESI2,
ENPP1,
SPARCL1,
NREP,
SLA-3,
IRF7,
DYNC1H1,
SLA-1,
P4HA1,
DNMT3A,
SEPHS2,
SGMS1,
CPE,
BIN1,
TNFRSF1B,
SLA-DQB1,
CD14,
APOBEC3F,
PDE4B,
KCND3,
KCNIP2,
UIMC1,
LOC100037950,
C9,
C6,
C8A,
C8B,
C8G,
LOC100037957,
CAPZA2,
CTSB,
SEPP1,
LOC100037968,
SLC7A7,
C2H19orf70,
ATP5J2,
PET100,
TOMM7,
NDUFC1,
SLIRP,
LOC100037988,
COX6C,
COX7C,
NDUFV2,
PSMB7,
RPL10A,
RPL14,
RPL27,
RPS21,
RPS26,
TMSB10,
TPM1,
ATPIF1,
KLF7,
RCHY1,
PCD1B,
CD1E,
SEP15,
CCL11,
CD72,
PVRL2,
COX6B,
RPS6,
CLEC7A,
RPL4,
EIF4E,
LGALS3,
SNRPE,
ZFAND5,
ADSS,
SDHD,
C5AR1,
BTG3,
GNA14,
NAGS,
TNMD,
ABCG8,
YWHAQ,
PGRMC2,
CYB561,
CNN3,
GNAS,
RBM39,
BRCA1,
EDN3,
KRT2,
HPS4,
BLOC1S5,
BLOC1S6,
RABGGTA,
MLPH,
ATP7B,
CRYZL1,
PNPLA3,
SRGN,
SPTAN1,
BIRC6,
HPS5
|
| 10429942 |
Matrix Biol. C R Flannery , C B Little , B Caterson , C E Hughes |
1999-06-01 | - |
| 9034191 |
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature M L Moss , S L Jin , M E Milla , D M Bickett , W Burkhart , H L Carter , W J Chen , W C Clay , J R Didsbury , D Hassler , C R Hoffman , T A Kost , M H Lambert , M A Leesnitzer , P McCauley , G McGeehan , J Mitchell , M Moyer , G Pahel , W Rocque , L K Overton , F Schoenen , T Seaton , J L Su , J D Becherer |
1997-02-20 |
Adam17,
Tnf,
ADAM17,
TNF,
ADAM17
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
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