| Type | Description |
|---|---|
| Definition | glycoprotein alpha-galactosyltransferase 1, pseudogene |
| Date | Results | Publications |
|---|---|---|
| 2018-01-06 12:28:00 | Silencing the GGTA1, CMAH and B4GalNT2 genes in pigs achieved a significant antigen reduction. Changing the porcine carbohydrate profile effectively mediates human antibody-mediated complement dependent cytoxicity. | 27100221 |
| 2018-01-06 11:35:00 | The peripheral blood mononuclear cells (PBMC) from the transgenic pigs were more resistant to lysis by pooled complement-preserved normal human serum than that from wild type (WT) pig. Accordingly, GGTA1 mutated piglets expressing hCD39 will provide a new organ source for xenotransplantation research | 27830476 |
| 2017-05-27 11:34:00 | Many waitlisted renal transplant patients have minimal xenoreactive antibody binding to the GGTA1/CMAH/B4GalNT2 knockout pig, but some HLA antibodies in sensitized patients cross-react with class I SLA. | 28114170 |
| 2016-07-16 10:11:00 | Silencing the porcine CMAH/GGTA1 genes necessary to avoid antibody-mediated rejection in a pig-to-human model also reduces the xenogeneic consumption of human platelets by the porcine liver. | 26906939 |
| 2015-08-01 10:27:00 | alpha 1-3-N-acetylgalactosaminyltransferase-knockout pig did not appear to have an advantage over the GalT-KO pig with respect to reactivity with human antibodies from a xenotransplantation perspective | 24219248 |
| Type | IDs |
|---|---|
| Synonymous | GGTA1, alpha1,3GT |
| Gene |
UniProtKB-ID:
GGTA1_PIG,
Q548W5_PIG,
A0A4X1UM53_PIG
UniprotKB:
P50127,
Q548W5,
A0A4X1UM53
UniParc:
UPI000002AA39,
UPI00000009A4,
UPI0006B1E8DF
EMBL:
AF221512,
AF221516,
L36535,
AF221513,
AF221509,
L36152,
AH010595,
AF221515,
AF221508
Ensembl:
ENSSSCG00035077948,
ENSSSCG00065002556,
ENSSSCG00070018338,
ENSSSCG00005038675,
ENSSSCG00000005518
KO:
ssc:396733
|
| Nucleutide sequences |
EMBL-CDS:
AAA73558.1,
AAA58775.1,
AAK01141.1,
AAK01142.1,
AAK28714.1
Ensembl_TRS:
ENSSSCT00000029057,
ENSSSCT00070036268,
ENSSSCT00005061930,
ENSSSCT00035107436,
ENSSSCT00070036264,
ENSSSCT00035107503,
ENSSSCT00035107350,
ENSSSCT00065003564,
ENSSSCT00065003559,
ENSSSCT00005061839,
ENSSSCT00070036262,
ENSSSCT00065003571,
ENSSSCT00005061820,
ENSSSCT00035107250,
ENSSSCT00065003518,
ENSSSCT00070036291
|
| Protein sequencees |
Ensembl_PRO:
ENSSSCP00070030316,
ENSSSCP00005038235,
ENSSSCP00065001321,
ENSSSCP00035046397,
ENSSSCP00070030321,
ENSSSCP00035046293,
ENSSSCP00065001318,
ENSSSCP00070030318,
ENSSSCP00005038317,
ENSSSCP00000020866,
ENSSSCP00035046449,
ENSSSCP00065001326,
ENSSSCP00065001292,
ENSSSCP00035046347,
ENSSSCP00005038248,
ENSSSCP00070030345
RefSeq:
NP_998975.1,
XP_020937342.1,
XP_013849271.1,
NP_001309985.1,
XP_020937353.1,
XP_013849269.1,
NP_001309984.1,
XP_005660459.1,
XP_013849268.1,
XP_005660456.1
|
| Others |
UniRef100:
UniRef100_A0A4X1UM53,
UniRef100_P50127
UniRef90:
UniRef90_P50127
UniRef50:
UniRef50_P50127
UniGene:
Ssc.8552
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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