| Type | Description |
|---|---|
| Definition | interferon regulatory factor 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:56:00 | PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production. | 31618847 |
| 2017-05-13 20:16:00 | The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex. | 27334592 |
| 2015-10-17 11:08:00 | Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha/beta production. | 25809915 |
| 2011-01-01 11:14:00 | The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta promoter activity in MARC-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3. | 20692306 |
| 2010-01-21 00:00:00 | proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro). | 17215286 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IRF3_PIG
UniprotKB:
Q764M6
UniParc:
UPI000022DE6A
EMBL:
AB116563
Ensembl:
ENSSSCG00040014662
KO:
ssc:396656
|
| Nucleutide sequences |
EMBL-CDS:
BAD06317.1
Ensembl_TRS:
ENSSSCT00040019663
|
| Protein sequencees |
Ensembl_PRO:
ENSSSCP00040008173
RefSeq:
NP_998935.1
|
| Others |
UniRef100:
UniRef100_Q764M6
UniRef90:
UniRef90_Q764M6
UniRef50:
UniRef50_Q764M6
UniGene:
Ssc.79511
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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