| Type | Description |
|---|---|
| Definition | TGF-beta activated kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-10 10:17:00 | Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2. Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin. | 28377500 |
| 2015-08-08 11:01:00 | Tak1 is dispensable in the Slpr-dependent process of dorsal closure; it does not induce or inhibit morphogenetic JNK signaling. | 24429281 |
| 2015-06-20 11:28:00 | The data data uncover Rab8, POSH, and TAK1 as regulators of synaptic growth responses and point to recycling endosome as a key compartment for synaptic growth regulation during neurodegenerative processes. | 25800055 |
| 2014-12-20 12:00:00 | The TAK1-associated Binding Protein 2 (TAB2) was linked with the TAK1-Trabid interaction through its Zinc finger domain that pacified the TAK1 signal | 24586180 |
| 2013-09-21 12:30:00 | When treated with autophagy inhibitors, the level of TAK1-induced cytotoxicity or cell death was significantly attenuated, indicating that TAK1 induces cytotoxic autophagic cell death. | 23532117 |
| Type | IDs |
|---|---|
| Synonymous | CG1388, CG18492, D-TAK, D-tak, D10, DTAK1, DTak, DTak1, DmTak1, Dmel\CG18492, TAK, TAK-1, TAK1, Tak, Tak 1, dTAK, dTAK-1, dTAK1, dTak, dTak1, dtak1, tak, tak1 |
| Gene |
UniProtKB-ID:
M3K7_DROME,
X2JFZ3_DROME
UniprotKB:
Q9V3Q6,
X2JFZ3
UniParc:
UPI0000075A0A,
UPI0002B8CDC9
EMBL:
AE014298,
AF199466,
AY051953
EnsemblGenome:
FBgn0026323
KO:
dme:Dmel_CG18492
|
| Nucleutide sequences |
EMBL-CDS:
AAF06815.1,
AAF50895.1,
AAK93377.1,
AHN59968.1
Gene_ORFName:
CG18492,
CG18492,
Dmel_CG18492
EnsemblGenome_TRS:
FBtr0077319,
FBtr0340404
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0077011,
FBpp0309350
RefSeq:
NP_001285498.1,
NP_524080.1
|
| Others |
UniRef100:
UniRef100_X2JFZ3,
UniRef100_Q9V3Q6
UniRef90:
UniRef90_Q9V3Q6,
UniRef90_X2JFZ3
UniRef50:
UniRef50_Q9V3Q6,
UniRef50_X2JFZ3
UniGene:
Dm.6425
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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