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396435 TPI1

396435

TPI1

triosephosphate isomerase 1

protein-coding

Gallus gallus

基因描述

Type Description
Definition triosephosphate isomerase 1

研究结论

Date Results Publications
2010-01-21 00:00:00 NMR study of wild-type (WT) TIM and a quintuple mutant (PGG/GGG). 17336327
2010-01-21 00:00:00 1st essential mode contributing to 34% of overall motion of dimer is strongly coupled to loop 6's closure over active site. Onset of collective motions at ns time scale due to dimerization has functional implications as to coordination of loop 6 closure. 18189421
2010-01-21 00:00:00 There is clear evidence for motion with an exchange rate constant consistent with opening and closing of triosephosphate isomerase active site loop (loop 6) being partially rate-limiting to catalytic throughput. 17455914
2010-01-21 00:00:00 The hypothesis that limited access to conformational space is a requirement for protein hinges involved in catalysis has been successfully tested with glycine N- and C-terminal hinge mutants of loop 6 of triosephosphate isomerase (TIM). 15350130

名称对应

Type IDs
Synonymous TIM
Gene
UniProtKB-ID: TPIS_CHICK
UniprotKB: P00940
UniParc: UPI00001713BD
EMBL: M11941, M11314
Ensembl: ENSGALG00000014526
KO: gga:396435
Nucleutide sequences
EMBL-CDS: AAA49094.1, AAA49095.1
Ensembl_TRS: ENSGALT00000023442, ENSGALT00000071768
Protein sequencees
Ensembl_PRO: ENSGALP00000023396, ENSGALP00000044536
RefSeq: NP_990782.1
Others
UniRef100: UniRef100_P00940
UniRef90: UniRef90_P00940
UniRef50: UniRef50_P00940
UniGene: Gga.4148

全选

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研究热度

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