| Type | Description |
|---|---|
| Definition | triosephosphate isomerase 1 |
| Date | Results | Publications |
|---|---|---|
| 2010-01-21 00:00:00 | NMR study of wild-type (WT) TIM and a quintuple mutant (PGG/GGG). | 17336327 |
| 2010-01-21 00:00:00 | 1st essential mode contributing to 34% of overall motion of dimer is strongly coupled to loop 6's closure over active site. Onset of collective motions at ns time scale due to dimerization has functional implications as to coordination of loop 6 closure. | 18189421 |
| 2010-01-21 00:00:00 | There is clear evidence for motion with an exchange rate constant consistent with opening and closing of triosephosphate isomerase active site loop (loop 6) being partially rate-limiting to catalytic throughput. | 17455914 |
| 2010-01-21 00:00:00 | The hypothesis that limited access to conformational space is a requirement for protein hinges involved in catalysis has been successfully tested with glycine N- and C-terminal hinge mutants of loop 6 of triosephosphate isomerase (TIM). | 15350130 |
| Type | IDs |
|---|---|
| Synonymous | TIM |
| Gene |
UniProtKB-ID:
TPIS_CHICK
UniprotKB:
P00940
UniParc:
UPI00001713BD
EMBL:
M11941,
M11314
Ensembl:
ENSGALG00000014526
KO:
gga:396435
|
| Nucleutide sequences |
EMBL-CDS:
AAA49094.1,
AAA49095.1
Ensembl_TRS:
ENSGALT00000023442,
ENSGALT00000071768
|
| Protein sequencees |
Ensembl_PRO:
ENSGALP00000023396,
ENSGALP00000044536
RefSeq:
NP_990782.1
|
| Others |
UniRef100:
UniRef100_P00940
UniRef90:
UniRef90_P00940
UniRef50:
UniRef50_P00940
UniGene:
Gga.4148
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
Yale University |
2 |
| 2 |
Swiss Institute for Bioinformatics |
1 |
| 3 |
European Molecular Biology Laboratory, Heidelberg, Germany. |
1 |
| 4 |
Brandeis University |
1 |
| 5 |
Harvard University |
1 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
G A Petsko |
3 |
| 2 |
J D Priddle |
2 |
| 3 |
A J Furth |
2 |
| 4 |
J D Milman |
2 |
| 5 |
R E Offord |
2 |