GJA8 - gap junction protein alpha 8-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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395846 GJA8

基因描述

Type	Description
Definition	gap junction protein alpha 8

研究结论

Date	Results	Publications
2021-04-03 13:34:00	Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens.	33180092
2019-10-26 11:33:00	Cx50 hemichannels mediate transport of reductant glutathione into lens fiber cells and protect cells against oxidative stress.	29487175
2017-05-13 22:04:00	the role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50.	27143357
2012-08-04 11:42:00	Results suggest that both caspase-1 and -3 are responsible for the cleavage at the C terminus of connexin 50 (Cx50) during lens development.	22418432
2011-07-16 10:36:00	Cx50 is phosphorylated in vivo by at Ser-395, which promotes increased dye permeability of Cx50 channels and plays an important role in metabolic coupling and transport in lens fibers	21454606

名称对应

Type	IDs
Synonymous	Cx45.6, Cx50, connexin-45.6
Gene	UniProtKB-ID: CXA8_CHICK, F1NRH7_CHICK UniprotKB: P36381, F1NRH7 UniParc: UPI0000ECD41E, UPI00001712FF EMBL: L24799, AADN05000689, D26333 Ensembl: ENSGALG00000015488 KO: gga:395846
Nucleutide sequences	EMBL-CDS: BAA05381.1, AAA57134.1 Ensembl_TRS: ENSGALT00000024977
Protein sequencees	Ensembl_PRO: ENSGALP00000036053 RefSeq: XP_015151286.1, XP_015151308.1, XP_015151300.1, XP_015151311.1, NP_990328.1, XP_015151294.1
Others	UniRef100: UniRef100_P36381, UniRef100_F1NRH7 UniRef90: UniRef90_P36381 UniRef50: UniRef50_P36381 UniGene: Gga.498, Gga.51510

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
33180092	Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens. J Cell Biol Jie Liu , Manuel A Riquelme , Zhen Li , Yuting Li , Yuxin Tong , Yumeng Quan , Cheng Pei , Sumin Gu , Jean X Jiang	2020-12-07	-
29487175	Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress. J. Cell. Sci. Wen Shi , Manuel A Riquelme , Sumin Gu , Jean X Jiang	2018-03-21	-
27143357	Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins. J Biol Chem Bernardo I Pinto , Isaac E GarcÃa , Amaury Pupo , Mauricio A Retamal , AgustÃn D MartÃnez , RamÃ³n Latorre , Carlos GonzÃ¡lez	2016-07-22	-
22418432	Developmental truncations of connexin 50 by caspases adaptively regulate gap junctions/hemichannels and protect lens cells against ultraviolet radiation. J Biol Chem Ke Wang , Sumin Gu , Xinye Yin , Susan T Weintraub , Zichun Hua , Jean X Jiang	2012-05-04	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21454606	Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. J Biol Chem Jialu Liu , Jose F Ek Vitorin , Susan T Weintraub , Sumin Gu , Qian Shi , Janis M Burt , Jean X Jiang	2011-05-13	-
21172802	Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50. J Cell Sci Jialu Liu , Ji Xu , Sumin Gu , Bruce J Nicholson , Jean X Jiang	2011-01-15	-
20395299	Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiation. J Biol Chem Qian Shi , Eric A Banks , X Sean Yu , Sumin Gu , Janelle Lauer , Gregg B Fields , Jean X Jiang	2010-06-11	-
19126675	Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner. J. Cell. Sci. Eric A Banks , Masoud M Toloue , Qian Shi , Zifei Jade Zhou , Jialu Liu , Bruce J Nicholson , Jean X Jiang	2009-02-01	GJA8
18649174	Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylation. Cell Commun Adhes Xinye Yin , Jialu Liu , Jean X Jiang	2008-05-01	-

研究热度

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