| Type | Description |
|---|---|
| Definition | UDP glucuronosyltransferase 1 family, polypeptide A1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:32:00 | Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. | 32093886 |
| 2020-09-26 13:03:00 | Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases. | 31211694 |
| 2019-06-29 11:09:00 | An AAV8 vector was developed expressing a codon-optimized human version of UGT1A1 from a liver-specific promoter. High doses of the vector rescued neonatal lethality in newborn UGT1 knockout (KO) mice, which serve as a model of Crigler-Najjar syndrome, and significantly increased survival from 5 to 270 days. | 29448836 |
| 2015-06-20 10:03:00 | data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development | 25200869 |
| 2014-01-25 12:20:00 | Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT-11 colorectal cancer treatment. | 24191041 |
| Type | IDs |
|---|---|
| Synonymous | Gnt1, UDPGT 1-1, UGT1A01, Udpgt-1a, UgtBr1 |
| Gene |
UniProtKB-ID:
UD11_MOUSE
UniprotKB:
Q63886
UniParc:
UPI0000021306
EMBL:
AY227194,
S64760,
BC093516
Ensembl:
ENSMUSG00000089960
KO:
mmu:394436
|
| Nucleutide sequences |
EMBL-CDS:
AAP48593.1,
AAH93516.1,
AAB26033.2
Ensembl_TRS:
ENSMUST00000073049
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000072803
RefSeq:
NP_964007.2
|
| Others |
UniRef100:
UniRef100_Q63886
UniRef90:
UniRef90_Q64550
UniRef50:
UniRef50_Q64550
UniGene:
Mm.300095
CCDS:
CCDS15143.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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