def6a - DEF6 guanine nucleotide exchange factor a-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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394015 def6a

基因描述

Type	Description
Definition	DEF6 guanine nucleotide exchange factor a

研究结论

Date	Results	Publications
2014-03-22 11:17:00	Swap70b and Def6a delineate Wnt11 and Wnt5b signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation	24177263
2012-03-03 10:04:00	def6 morphants phenocopy Wnt5b mutants and ectopic overexpression of def6 essentially rescues Wnt5b morphants, indicating a novel role for def6 as a central GEF downstream of Wnt5b signaling	22039507

名称对应

Type	IDs
Synonymous	Def6, zgc:63721
Gene	UniProtKB-ID: DEFI6_DANRE UniprotKB: Q7SYB5 UniParc: UPI00001B2C96 EMBL: AY391419, BX004884, BC054935 Ensembl: ENSDARG00000012247 KO: dre:394015
Nucleutide sequences	EMBL-CDS: AAQ91231.1, CAK11143.1, AAH54935.1 Gene_ORFName: zgc:63721, si:dkey-6n6.5 Ensembl_TRS: ENSDART00000005359
Protein sequencees	Ensembl_PRO: ENSDARP00000025016 RefSeq: NP_957334.1, XP_017212790.1
Others	UniRef100: UniRef100_Q7SYB5 UniRef90: UniRef90_Q7SYB5 UniRef50: UniRef50_Q9H4E7 UniGene: Dr.26673

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
31415728	Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Gen. Comp. Endocrinol. Diego Safian , Jan Bogerd , RÃ¼diger W Schulz	2019-12-01	-
31053140	Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Mol Brain Morgan Newman , Nhi Hin , Stephen Pederson , Michael Lardelli	2019-05-03	-
27189481	Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. BMC Genomics Jeremy Pasquier , CÃ©dric Cabau , Thaovi Nguyen , Elodie Jouanno , Dany Severac , Ingo Braasch , Laurent Journot , Pierre Pontarotti , Christophe Klopp , John H Postlethwait , Yann Guiguen , Julien Bobe	2016-05-18	-
26469318	RFX transcription factors are essential for hearing in mice. Nat Commun Ran Elkon , Beatrice Milon , Laura Morrison , Manan Shah , Sarath Vijayakumar , Manoj Racherla , Carmen C Leitch , Lorna Silipino , Shadan Hadi , MichÃ¨le Weiss-Gayet , EmmanuÃ¨le Barras , Christoph D Schmid , Aouatef Ait-Lounis , Ashley Barnes , Yang Song , David J Eisenman , Efrat Eliyahu , Gregory I Frolenkov , Scott E Strome , BÃ©nÃ©dicte Durand , Norann A Zaghloul , Sherri M Jones , Walter Reith , Ronna Hertzano	2015-10-15	-
25601102	Eumetazoan cryptochrome phylogeny and evolution. Genome Biol Evol Marion F Haug , Matthias Gesemann , Viktor LazoviÄ , Stephan C F Neuhauss	2015-02-01	cry1aa, si:dkeyp-27e10.3, btbd11b, srsf3b, pcloa, adora1b, ppfibp2a, adm2b, ampd2a, stk38b, eps8l3a, sema3aa, sema3ab, pparda, ppardb, ric8b, tnnt2c, rbbp5, eps8l3b, def6a, calub, mical3a, adm2a, cacna1sb, tmem243b, stk38a, lmf2b, dram2b, calua, tspan9b, tspan33a, dennd2db, prkca, apobec2a, tmem243a, parp12b, cry1ab, tspan9a, tmtc2b, srgap1b, si:ch211-1e14.1, mterf2, shank3a, cept1a, nuak2, rpl13a, elf3, nuak1a, si:dkey-222f8.3, ppfibp1b, endouc, btbd11a, prmt8b, cracr2ab, tmtc2a, ppfibp1a, stab2, pclob, shank3b, si:dkey-153k10.9, mical3b, gpr37l1a, parp12a, tspan33b, gpr37l1b, srgap1a, cacna1sa, cept1b, ampd2b, lmf2a, cry1ba, dennd2da, cry2, cry4, cry5, cry1bb
24177263	Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function. Dev. Biol. Xiaoou Xu , Wai Ho Shuen , Chen Chen , Katerina Goudevenou , Peter Jones , Fred Sablitzky	2014-02-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
22039507	Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling. PLoS ONE Katerina Goudevenou , Paul Martin , Yu-Jung Yeh , Peter Jones , Fred Sablitzky	2011-01-01	wnt5b, chd, egr2b, gsc, ta, pax2a, myod1, dlx3b, bmp4, bmp2b, def6a, cdx4
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-

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