| Type | Description |
|---|---|
| Definition | retinoid isomerohydrolase RPE65 a |
| Date | Results | Publications |
|---|---|---|
| 2019-03-16 11:13:00 | Here, we developed a zebrafish transgenic model (rpe65a:nfsB-eGFP) that enabled ablation of large swathes of mature RPE. RPE ablation resulted in rapid RPE degeneration, as well as degeneration of Bruch's membrane and underlying photoreceptors. Using this model, we demonstrate for the first time that zebrafish are capable of regenerating a functional RPE monolayer after RPE ablation. | 30695061 |
| Type | IDs |
|---|---|
| Synonymous | RPE56a, rpepa, zgc:73213 |
| Gene |
UniProtKB-ID:
RP65A_DANRE
UniprotKB:
Q6PBW5
UniParc:
UPI00001D94D0
EMBL:
BC059559,
FP102801,
AY646886
Ensembl:
ENSDARG00000007480
KO:
dre:393724
|
| Nucleutide sequences |
EMBL-CDS:
AAH59559.1,
AAV65107.1
Ensembl_TRS:
ENSDART00000004533
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000017189
RefSeq:
NP_957045.1
|
| Others |
UniRef100:
UniRef100_Q6PBW5
UniRef90:
UniRef90_Q6PBW5
UniRef50:
UniRef50_Q9YGX2
UniGene:
Dr.12451
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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