| Type | Description |
|---|---|
| Definition | lymphocyte cytosolic protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:04:00 | Targeting adaptor protein SLP76 of as a therapeutic approach for lethal sepsis. | 33436632 |
| 2020-01-11 12:09:00 | Findings reveal that ADAP acts upstream of SLP-76 to convert labile, Ca(2+)-competent microclusters into stable adhesive junctions with enhanced signaling potential. | 30305305 |
| 2018-05-19 10:55:00 | a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. | 28644030 |
| 2017-09-16 11:02:00 | These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. | 28289074 |
| 2017-08-05 11:54:00 | LAT and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement. | 27875277 |
| Type | IDs |
|---|---|
| Synonymous | SLP-76, SLP76 |
| Gene |
UniProtKB-ID:
LCP2_HUMAN
UniprotKB:
Q13094
UniParc:
UPI000012E2AE
EMBL:
U20158,
BC016618,
AK292890,
CH471062,
BT007273
Ensembl:
ENSG00000043462
KO:
hsa:3937
|
| Nucleutide sequences |
EMBL-CDS:
BAF85579.1,
AAP35937.1,
EAW61479.1,
AAH16618.1,
AAC50135.1
Ensembl_TRS:
ENST00000046794
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000046794
RefSeq:
NP_005556.1
|
| Others |
UniRef100:
UniRef100_Q13094
UniRef90:
UniRef90_Q13094
UniRef50:
UniRef50_Q13094
UniGene:
Hs.304475
CCDS:
CCDS47339.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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