| Type | Description |
|---|---|
| Definition | integrin-linked kinase |
| Date | Results | Publications |
|---|---|---|
| 2019-06-01 10:04:00 | Using the ILK deficient zebrafish heart failure mutant main squeeze (msq), which shows reduced PKB phosphorylation and thereby impaired cardiac contractile force, we identified here, in an automated small compound screen, the protein phosphatase inhibitors calyculin A and okadaic acid significantly restoring myocardial contractile function by reconstituting PKB phosphorylation in msq ILK-deficient zebrafish embryos. | 30463267 |
| 2010-01-21 00:00:00 | The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk. | 17646580 |
| 2010-01-21 00:00:00 | Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix. | 18436206 |
| 2010-01-21 00:00:00 | Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene. | 16921028 |
| Type | IDs |
|---|---|
| Synonymous | zgc:65842 |
| Gene |
UniProtKB-ID:
Q6PHD6_DANRE
UniprotKB:
Q6PHD6
UniParc:
UPI00001BD842
EMBL:
AL928852,
BC056593
Ensembl:
ENSDARG00000056964
KO:
dre:393543
|
| Nucleutide sequences |
EMBL-CDS:
AAH56593.1
Ensembl_TRS:
ENSDART00000079528,
ENSDART00000192401
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000073983,
ENSDARP00000153672
RefSeq:
NP_956865.1
|
| Others |
UniRef100:
UniRef100_Q6PHD6
UniRef90:
UniRef90_Q6PHD6
UniRef50:
UniRef50_Q13418
UniGene:
Dr.77678
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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