| Type | Description |
|---|---|
| Definition | Ubiquitin protein ligase E3A |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:30:00 | A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster. | 30787400 |
| 2018-07-28 11:31:00 | Drosophila endogenously expresses Dube3a (fly UBE3A homolog) in glial cells and neurons. A robust seizure-like phenotype was observed in flies overexpressing Dube3a in glial cells, but not neurons. Glial-specific knockdown of ATPalpha also produced seizure-like behavior, and this phenotype was rescued by simultaneously overexpressing ATPalpha and Dube3a in glia. | 28888970 |
| 2017-05-13 14:25:00 | Negative regulation of Tkv by Ube3a was conserved in mammalian cells. These results reveal a critical role for Ube3a in regulating NMJ synapse development by repressing BMP signaling. This study sheds new light onto the neuronal functions of UBE3A and provides novel perspectives for understanding the pathogenesis of UBE3A-associated disorders. | 27232889 |
| 2015-08-15 10:48:00 | Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies. | 25935478 |
| 2014-08-23 12:15:00 | Rpn10 is targeted for degradation by Ube3a. | 24292889 |
| Type | IDs |
|---|---|
| Synonymous | AS, As, CG6190, Dmel\CG6190, Dube3A, Dube3a, NM_140195.2, UBE3A, dUBE3A, dUbe3A, dUbe3a, das, dube3A, dube3a, ube3a |
| Gene |
UniProtKB-ID:
Q9VTH1_DROME
UniprotKB:
Q9VTH1
UniParc:
UPI000007B363
EMBL:
AY069489,
AE014296
EnsemblGenome:
FBgn0061469
KO:
dme:Dmel_CG6190
|
| Nucleutide sequences |
EMBL-CDS:
AAF50078.1,
AAL39634.1
Gene_ORFName:
Dmel_CG6190,
CG6190
EnsemblGenome_TRS:
FBtr0076186
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0075916
RefSeq:
NP_648452.1
|
| Others |
UniRef100:
UniRef100_Q9VTH1
UniRef90:
UniRef90_Q9VTH1
UniRef50:
UniRef50_Q9VTH1
UniGene:
Dm.928
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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