| Type | Description |
|---|---|
| Definition | Death regulator Nedd2-like caspase |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 13:27:00 | such Egr-induced necrosis depends on the catalytic activity of the initiator caspase Dronc and the input from JNK signaling but is independent of their roles in apoptosis. Further mosaic analysis with mutants of scribble (scrib), suggests that Egr/JNK-mediated apoptosis and necrosis establish a two-layered defense system to inhibit the oncogenic growth of scrib mutant cells | 31409797 |
| 2020-01-04 11:02:00 | in developing epithelial thorax, caspase 3 has a role in non-apoptotic cell motility, while Dronc activation regulates myosin levels and delays wound healing | 30770378 |
| 2018-06-09 11:41:00 | Dronc plays a dual role that can either initiate DNA damage response or apoptosis. | 28751499 |
| 2018-02-17 11:43:00 | Activation of epidermal Dronc induces TNF-dependent but effector caspase-independent nociceptive sensitization in the absence of UV. In addition, knockdown of Dronc attenuated nociceptive sensitization induced by full-length TNF/Eiger but not by a constitutively soluble form. UV irradiation induced TNF production in both in vitro and in vivo | 28492538 |
| 2018-01-20 10:42:00 | Dronc protein fails to accumulate in epithelial cells with impaired proteasome function suggesting that it is not degraded by the proteasome. | 27104928 |
| Type | IDs |
|---|---|
| Synonymous | CG8090, CG8091, DRONC, Dmel\CG8091, Dronc/Casp9, Nc, Nc\Dronc, anon-EST:GreesD6, anon-EST:GressD6, anon-WO0118547.313, caspase-9, dronc |
| Gene |
UniProtKB-ID:
DRONC_DROME
UniprotKB:
Q9XYF4
UniParc:
UPI0000081FFD
EMBL:
AE014296,
AF104357,
AJ242796,
AY058747
EnsemblGenome:
FBgn0026404
KO:
dme:Dmel_CG8091
|
| Nucleutide sequences |
EMBL-CDS:
AAD26625.1,
AAF50180.1,
AAL13976.1,
CAB53565.1
Gene_ORFName:
CG8091
EnsemblGenome_TRS:
FBtr0076347
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0076076
RefSeq:
NP_524017.1
|
| Others |
UniRef100:
UniRef100_Q9XYF4
UniRef90:
UniRef90_Q9XYF4
UniRef50:
UniRef50_Q9XYF4
UniGene:
Dm.3230
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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