| Type | Description |
|---|---|
| Definition | laminin subunit alpha 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:27:00 | In diverse models, laminins alpha-4 (LAMA4) and alpha-5 (LAMA5) were differentially regulated. Immunity was associated with decreased LAMA4:LAMA5 ratio, while tolerance was associated with an increased ratio. LAMA4inhibited CD4+ T-cell proliferation and Th1, Th2, and Th17 polarization but favored Treg induction. LAMA4 and LAMA5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively. | 31343575 |
| 2020-05-23 11:50:00 | Downregulation of the LAMA4 gene inhibits the proliferation, migration, and invasion of extravillous trophoblasts to suppress the expression of vascular factors, leading to the occurrence or development of preeclampsia. | 31842202 |
| 2020-04-11 12:34:00 | High LAMA4 expression is associated with inflammation in asthma. | 31553662 |
| 2018-11-17 10:45:00 | High LAMA4 expression is associated with gastric cancer. | 30015861 |
| 2018-01-06 10:11:00 | Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) | 27614294 |
| Type | IDs |
|---|---|
| Synonymous | CMD1JJ, LAMA3, LAMA4*-1 |
| Gene |
UniProtKB-ID:
LAMA4_HUMAN,
Q5D044_HUMAN,
A0A0A0MQS9_HUMAN,
A0A0A0MTC7_HUMAN
UniprotKB:
Q16363,
Q5D044,
A0A0A0MQS9,
A0A0A0MTC7
UniParc:
UPI000153D541,
UPI000013C937,
UPI0000161B53,
UPI0000071354,
UPI0000DBEE70,
UPI000257807D
EMBL:
KF510935,
BC066552,
S78569,
BT006690,
Y14240,
AB210027,
BC004241,
X91171,
X70904,
Z99289,
AL590106,
X76939
Ensembl:
ENSG00000112769
KO:
hsa:3910
|
| Nucleutide sequences |
EMBL-CDS:
CAA54258.1,
BAE06109.1,
CAA50261.1,
AAH04241.1,
CAA74636.1,
AAB34635.1,
CAA62596.1,
AAP35336.1,
AAH66552.1
Ensembl_TRS:
ENST00000368638,
ENST00000455073,
ENST00000453937,
ENST00000230538,
ENST00000522006,
ENST00000389463,
ENST00000424408
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357627,
ENSP00000408604,
ENSP00000398226,
ENSP00000230538,
ENSP00000429488,
ENSP00000374114,
ENSP00000416470
RefSeq:
XP_005267041.2,
XP_005267040.2,
NP_002281.3,
NP_001098678.1,
XP_016866343.1,
NP_001098676.2,
NP_001098677.2,
NP_001098679.1
|
| Others |
UniRef100:
UniRef100_Q5D044,
UniRef100_Q16363,
UniRef100_A0A0A0MQS9,
UniRef100_A0A0A0MTC7
UniRef90:
UniRef90_Q16363,
UniRef90_Q16363-2
UniRef50:
UniRef50_Q16363
UniGene:
Hs.654572
CCDS:
CCDS43491.1,
CCDS43492.1,
CCDS34514.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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