| Type | Description |
|---|---|
| Definition | nervous wreck |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 10:44:00 | This study examines the interactions of the F-BAR domain of nervous wreck (Nwk) with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 )-containing membranes using coarse-grained molecular dynamics. | 30803020 |
| 2018-01-27 11:42:00 | In Drosophila neurons, Nwk autoregulation restricts SH3a domain-dependent synaptopod formation, synaptic growth, and actin organization. Our results define structural rearrangements in Nwk that control F-BAR-membrane interactions as well as SH3 domain activities, and suggest that these two functions are tightly coordinated in vitro and in vivo. | 27601635 |
| 2016-10-08 12:06:00 | SH3PX1 promotes neurotransmitter release presynaptically, at least in part through functional interactions with Nwk. | 26567222 |
| 2014-03-01 13:03:00 | Nwk-induced scallops can be extended by cytoskeletal forces to produce protrusions at the plasma membrane. | 23761074 |
| 2011-06-18 10:35:00 | The results define a presynaptic trafficking pathway mediated by SNX16, NWK, and the ESCRT complex that functions to control synaptic growth signaling at the interface between endosomal compartments. | 21464232 |
| Type | IDs |
|---|---|
| Synonymous | CG43479, CG4641, CG4684, Dmel\CG43479, Dmel_CG4641, Dmel_CG4684, NWK, Nwk |
| Gene |
UniProtKB-ID:
NWK_DROME
UniprotKB:
X2JAU8
UniParc:
UPI000264EC3C,
UPI0003954CD2,
UPI0003954CAE,
UPI0003954CBC,
UPI000264EC43,
UPI000264EC3D,
UPI0003954C92,
UPI000264EC3B,
UPI0003954CDD
EMBL:
AE014296
EnsemblGenome:
FBgn0263456
KO:
dme:Dmel_CG43479
|
| Nucleutide sequences |
EMBL-CDS:
AHN58018.1,
AHN58020.1,
AAF50313.4,
AHN58022.1,
AHN58019.1,
AFH04360.1,
AFH04363.1,
AFH04361.1,
AFH04362.1,
AHN58021.1
Gene_ORFName:
CG43479
EnsemblGenome_TRS:
FBtr0331857,
FBtr0309277,
FBtr0344239,
FBtr0344242,
FBtr0309278,
FBtr0309276,
FBtr0344241,
FBtr0344240,
FBtr0344238,
FBtr0309280
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0310642,
FBpp0310646,
FBpp0310643,
FBpp0301204,
FBpp0304241,
FBpp0310644,
FBpp0301207,
FBpp0301203,
FBpp0310645,
FBpp0301205
RefSeq:
NP_001286995.1,
NP_001286993.1,
NP_648290.3,
NP_001246691.1,
NP_001286997.1,
NP_001246692.1,
NP_001286994.1,
NP_001286996.1,
NP_001246690.1,
NP_001246689.1
|
| Others |
UniRef100:
UniRef100_X2JAU8
UniRef90:
UniRef90_X2JAU8
UniRef50:
UniRef50_X2JAU8
UniGene:
Dm.3847
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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