| Type | Description |
|---|---|
| Definition | orb2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:47:00 | Implications of the Orb2 Amyloid Structure in Huntington's Disease. | 32967102 |
| 2018-07-28 10:09:00 | We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation. | 29105522 |
| 2018-06-02 11:20:00 | The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core. | 27922050 |
| 2018-03-10 12:19:00 | Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains. | 28763009 |
| 2017-08-26 11:14:00 | Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f... | 28700922 |
| Type | IDs |
|---|---|
| Synonymous | CG43113, CG43782, CG5735, Dmel\CG43782, Dmel_CG43113, Dmel_CG5735, Dmel_CG5741, Orb2, Orb2A, Orb2B, anon-WO0140519.222, cg5735 |
| Gene |
UniProtKB-ID:
ORB2_DROME,
A4V1P2_DROME
UniprotKB:
Q9VSR3,
A4V1P2
UniParc:
UPI00000753B9,
UPI00000765F2
EMBL:
AY052043,
AE014296,
AY060352
EnsemblGenome:
FBgn0264307
KO:
dme:Dmel_CG43782
|
| Nucleutide sequences |
EMBL-CDS:
AAL25391.1,
AAF50352.1,
AAK93467.1,
AAF50350.1,
AAF50351.1,
AGB94303.1,
AAN11975.1
Gene_ORFName:
CG43782,
CG43782,
Dmel_CG43782
EnsemblGenome_TRS:
FBtr0331512,
FBtr0331511,
FBtr0331514,
FBtr0331513,
FBtr0331515,
FBtr0331515,
FBtr0331514,
FBtr0331513,
FBtr0331512
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0303905,
FBpp0303903,
FBpp0303902,
FBpp0303901,
FBpp0303904,
FBpp0303905,
FBpp0303902,
FBpp0303903,
FBpp0303904
RefSeq:
NP_001356977.1,
NP_001356978.1,
NP_729428.1,
NP_729427.1,
NP_648266.1,
NP_001261608.1,
NP_729429.1
|
| Others |
UniRef100:
UniRef100_Q9VSR3
UniRef90:
UniRef90_Q9VSR3
UniRef50:
UniRef50_Q9VSR3
UniGene:
Dm.4024
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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