| Type | Description |
|---|---|
| Definition | MAF bZIP transcription factor A |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:59:00 | The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival. | 31822558 |
| 2020-06-13 10:04:00 | These findings suggest that PIASy binds to MafA through the SAP domain and negatively regulates the insulin gene promoter through a novel SIM1-dependent mechanism. | 31614335 |
| 2019-07-27 13:29:00 | confirm the association of miR-204 with a beta cell endocrine phenotype in human pancreatic islets, but do not support its direct role in regulating the levels of insulin mRNA through MAFA | 29070792 |
| 2018-07-21 12:10:00 | We investigated a large pedigree with autosomal dominant inheritance of diabetes mellitus or insulinomatosis, an adult-onset condition of recurrent hyperinsulinemic hypoglycemia caused by multiple insulin-secreting neuroendocrine tumors of the pancreas. Using exome sequencing, we identified a missense MAFA mutation (p.Ser64Phe, c.191C>T) segregating with both phenotypes of insulinomatosis and diabetes. | 29339498 |
| 2018-06-09 11:53:00 | PDX1, Neurogenin-3, and MAFA are critical transcription regulators for beta cell development and regeneration. (Review) | 29096722 |
| Type | IDs |
|---|---|
| Synonymous | INSDM, RIPE3b1, hMafA |
| Gene |
UniProtKB-ID:
MAFA_HUMAN
UniprotKB:
Q8NHW3
UniParc:
UPI00001B0366
EMBL:
AC105118,
AY083269,
AB086960
Ensembl:
ENSG00000182759
KO:
hsa:389692
|
| Nucleutide sequences |
EMBL-CDS:
BAC20389.1,
AAL89527.1
Ensembl_TRS:
ENST00000333480
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000328364
RefSeq:
NP_963883.2
|
| Others |
UniRef100:
UniRef100_Q8NHW3
UniRef90:
UniRef90_Q8NHW3
UniRef50:
UniRef50_Q8NHW3
UniGene:
Hs.521914
CCDS:
CCDS34955.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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