ALKAL1 - ALK and LTK ligand 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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389658 ALKAL1

基因描述

Type	Description
Definition	ALK and LTK ligand 1

研究结论

Date	Results	Publications
2018-07-21 12:08:00	activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates	29317532
2016-08-27 11:55:00	In conclusion, these data show that ALK is robustly activated by the FAM150A/B ligands.	26418745
2016-08-20 12:15:00	Data show that leukocyte tyrosine kinase (LTK) ligand FAM150A (augmentor-beta; AUG-beta) is specific for LTK and only weakly binds to anaplastic lymphoma kinase (ALK).	26630010
2015-04-18 11:07:00	Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation.	25331893

名称对应

Type	IDs
Synonymous	AUGA, AUGB, FAM150A, UNQ9433
Gene	UniProtKB-ID: ALKL1_HUMAN UniprotKB: Q6UXT8 UniParc: UPI00001D6942, UPI000189A922 EMBL: AC013650, BC130641, BC144534, BC130643, AY358213 Ensembl: ENSG00000196711 KO: hsa:389658
Nucleutide sequences	EMBL-CDS: AAI30644.1, AAI30642.1, AAQ88580.1, AAI44535.1 Gene_ORFName: UNQ9433/PRO34745 Ensembl_TRS: ENST00000358543, ENST00000523939
Protein sequencees	Ensembl_PRO: ENSP00000351345, ENSP00000430953 RefSeq: NP_997296.1
Others	UniRef100: UniRef100_Q6UXT8 UniRef90: UniRef90_Q6UXT8 UniRef50: UniRef50_Q6UXT8 UniGene: Hs.527111 CCDS: CCDS6150.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
29317532	ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells. Proc. Natl. Acad. Sci. U.S.A. Andrey Fadeev , Patricia Mendoza-Garcia , Uwe Irion , Jikui Guan , Kathrin Pfeifer , Stephanie Wiessner , Fabrizio Serluca , Ajeet Pratap Singh , Christiane NÃ¼sslein-Volhard , Ruth H Palmer	2018-01-23	-
27609421	TNIP2 is a Hub Protein in the NF-ÎºB Network with Both Protein and RNA Mediated Interactions. Mol Cell Proteomics Charles A S Banks , Gina Boanca , Zachary T Lee , Cassandra G Eubanks , Gaye L Hattem , Allison Peak , Lauren E Weems , Juliana J Conkright , Laurence Florens , Michael P Washburn	2016-11-01	-
26630010	Augmentor Î± and Î² (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. Proc. Natl. Acad. Sci. U.S.A. Andrey V Reshetnyak , Phillip B Murray , Xiarong Shi , Elizabeth S Mo , Jyotidarsini Mohanty , Francisco Tome , Hanwen Bai , Murat Gunel , Irit Lax , Joseph Schlessinger	2016-12-29	-
26418745	FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife Jikui Guan , Ganesh Umapathy , Yasuo Yamazaki , Georg Wolfstetter , Patricia Mendoza , Kathrin Pfeifer , Ateequrrahman Mohammed , Fredrik Hugosson , Hongbing Zhang , Amy W Hsu , Robert Halenbeck , Bengt Hallberg , Ruth H Palmer	2015-01-01	FAM150B, FAM150A
25331893	Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Proc. Natl. Acad. Sci. U.S.A. Hongbing Zhang , Lily I Pao , Aileen Zhou , Arthur D Brace , Robert Halenbeck , Amy W Hsu , Thomas L Bray , Kevin Hestir , Elizabeth Bosch , Ernestine Lee , Gang Wang , Haixia Liu , Brian R Wong , W Michael Kavanaugh , Lewis T Williams	2014-11-04	FAM150B, FAM150A, LTK
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
12975309	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. Hilary F Clark , Austin L Gurney , Evangeline Abaya , Kevin Baker , Daryl Baldwin , Jennifer Brush , Jian Chen , Bernard Chow , Clarissa Chui , Craig Crowley , Bridget Currell , Bethanne Deuel , Patrick Dowd , Dan Eaton , Jessica Foster , Christopher Grimaldi , Qimin Gu , Philip E Hass , Sherry Heldens , Arthur Huang , Hok Seon Kim , Laura Klimowski , Yisheng Jin , Stephanie Johnson , James Lee , Lhney Lewis , Dongzhou Liao , Melanie Mark , Edward Robbie , Celina Sanchez , Jill Schoenfeld , Somasekar Seshagiri , Laura Simmons , Jennifer Singh , Victoria Smith , Jeremy Stinson , Alicia Vagts , Richard Vandlen , Colin Watanabe , David Wieand , Kathryn Woods , Ming-Hong Xie , Daniel Yansura , Sothy Yi , Guoying Yu , Jean Yuan , Min Zhang , Zemin Zhang , Audrey Goddard , William I Wood , Paul Godowski , Alane Gray	2003-10-01	Sdhd, SIGLEC14, LOC100127951, LOC100128035, LOC100128644, LOC100128816, LPEQ6126, QIQN5815, UNQ6494, EPWW6493, LOC100130071, LOC100130428, LRRC70, LOC100130916, LOC100131131, CD300LD, LOC100131541, LOC100131826, LOC100131943, LOC100132099, LOC100133106, C17orf99, INSL5, PET117, TOM1, SH2D3C, SH2D3A, LOC100506242, CASP12, HCG8, LOC100507646, LOC100508226, FAM24B-CUZD1, GPC6, PINK1-AS, PPIF, CDH16, CLEC3A, DHRS9, CNIH1, MPZL2, ANGPTL7, LRRC17, FSTL3, CWC27, CNPY2, B3GNT3, CCL26, PRG3, SPON2, LRRN2, GPNMB, SEMA6B, SEMA4B, FBLN5, LOC105377021, AGR2, OLFM4, COLEC10, LEFTY1, TNFSF13B, CNPY3, YME1L1, ARID5A, HCST, LYVE1, DHRS4, UTS2, BTNL3, PRSS21, SLC27A3, KLK11, ADAM30, ADAMTS13, CACFD1, PRSS23, CLASRP, FICD, ERLIN2, WIF1, KLK8, NXPH4, NXPH3, MAN1B1, RDH13, GLMP, MGAT4B, B4GALT7, CFAP36, IZUMO4, CHST14, CASC4, VSIG4, SCRG1, TEX261, SIGLEC11, LACTB, PGLYRP2, SLC25A25
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-

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