Type | Description |
---|---|
Definition | GDNF family receptor alpha like |
Date | Results | Publications |
---|---|---|
2020-10-31 13:17:00 | Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. | 32661391 |
Type | IDs |
---|---|
Synonymous | C6orf144, GRAL, UNQ9356, bA360D14.1 |
Gene |
UniProtKB-ID:
GFRAL_HUMAN
UniprotKB:
Q6UXV0
UniParc:
UPI000023780D
EMBL:
AY358198,
AL592426
Ensembl:
ENSG00000187871
KO:
hsa:389400
|
Nucleutide sequences |
EMBL-CDS:
AAQ88565.1
Gene_ORFName:
UNQ9356/PRO34128
Ensembl_TRS:
ENST00000340465
|
Protein sequencees |
Ensembl_PRO:
ENSP00000343636
RefSeq:
NP_997293.2
|
Others |
UniRef100:
UniRef100_Q6UXV0
UniRef90:
UniRef90_Q6UXV0
UniRef50:
UniRef50_Q6UXV0
UniGene:
Hs.526967
CCDS:
CCDS4957.1
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
暂无数据
Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
---|---|---|---|
32661391 |
Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. Nat Med Rowena Suriben , Michael Chen , Jared Higbee , Julie Oeffinger , Richard Ventura , Betty Li , Kalyani Mondal , Zhengyu Gao , Dina Ayupova , Pranali Taskar , Diana Li , Shelley R Starck , Hung-I Harry Chen , Michele McEntee , Subhash D Katewa , Van Phung , Marilyn Wang , Avantika Kekatpure , Damodharan Lakshminarasimhan , Andre White , Andrea Olland , Raj Haldankar , Mark J Solloway , Jer-Yuan Hsu , Yan Wang , Jie Tang , Darrin A Lindhout , Bernard B Allan |
2020-08-01 | - |
31059266 |
Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics. J. Proteome Res. Xiangling Chen , Dayun Lu , Jing Gao , Hongwen Zhu , Yanting Zhou , Daming Gao , Hu Zhou |
2019-06-07 | - |
29676528 |
E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. FEBS J. Richa Khanna , Vidhya Krishnamoorthy , Veena K Parnaik |
2018-06-01 | - |
28953886 |
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature Jer-Yuan Hsu , Suzanne Crawley , Michael Chen , Dina A Ayupova , Darrin A Lindhout , Jared Higbee , Alan Kutach , William Joo , Zhengyu Gao , Diana Fu , Carmen To , Kalyani Mondal , Betty Li , Avantika Kekatpure , Marilyn Wang , Teresa Laird , Geoffrey Horner , Jackie Chan , Michele McEntee , Manuel Lopez , Damodharan Lakshminarasimhan , Andre White , Sheng-Ping Wang , Jun Yao , Junming Yie , Hugo Matern , Mark Solloway , Raj Haldankar , Thomas Parsons , Jie Tang , Wenyan D Shen , Yu Alice Chen , Hui Tian , Bernard B Allan |
2017-10-12 | - |
28846099 |
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat. Med. Linda Yang , Chih-Chuan Chang , Zhe Sun , Dennis Madsen , Haisun Zhu , Søren B Padkjær , Xiaoai Wu , Tao Huang , Karin Hultman , Sarah J Paulsen , Jishu Wang , Anne Bugge , Jane Boesen Frantzen , Per Nørgaard , Jacob Fuglsbjerg Jeppesen , Zhiru Yang , Anna Secher , Haibin Chen , Xun Li , Linu Mary John , Bing Shan , Zhenhua He , Xiang Gao , Jing Su , Kristian T Hansen , Wei Yang , Sebastian Beck Jørgensen |
2017-10-01 | - |
28846097 |
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat. Med. Shannon E Mullican , Xiefan Lin-Schmidt , Chen-Ni Chin , Jose A Chavez , Jennifer L Furman , Anthony A Armstrong , Stephen C Beck , Victoria J South , Thai Q Dinh , Tanesha D Cash-Mason , Cassandre R Cavanaugh , Serena Nelson , Chichi Huang , Michael J Hunter , Shamina M Rangwala |
2017-10-01 | - |
28846098 |
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat. Med. Paul J Emmerson , Feng Wang , Yong Du , Qian Liu , Richard T Pickard , Malgorzata D Gonciarz , Tamer Coskun , Matthew J Hamang , Dana K Sindelar , Kimberly K Ballman , Lisa A Foltz , Avinash Muppidi , Jorge Alsina-Fernandez , Gavin C Barnard , Jason X Tang , Xilin Liu , Xudong Mao , Robert Siegel , John H Sloan , Pamela J Mitchell , Bei B Zhang , Ruth E Gimeno , Bei Shan , Xinle Wu |
2017-10-01 | - |
21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
16086688 |
Identification, expression and functional characterization of the GRAL gene. J. Neurochem. Zhihua Li , Bingwei Wang , Xuefei Wu , Shi-Yuan Cheng , Luminita Paraoan , Jiawei Zhou |
2005-10-01 | - |
14574404 |
The DNA sequence and analysis of human chromosome 6. Nature A J Mungall , S A Palmer , S K Sims , C A Edwards , J L Ashurst , L Wilming , M C Jones , R Horton , S E Hunt , C E Scott , J G R Gilbert , M E Clamp , G Bethel , S Milne , R Ainscough , J P Almeida , K D Ambrose , T D Andrews , R I S Ashwell , A K Babbage , C L Bagguley , J Bailey , R Banerjee , D J Barker , K F Barlow , K Bates , D M Beare , H Beasley , O Beasley , C P Bird , S Blakey , S Bray-Allen , J Brook , A J Brown , J Y Brown , D C Burford , W Burrill , J Burton , C Carder , N P Carter , J C Chapman , S Y Clark , G Clark , C M Clee , S Clegg , V Cobley , R E Collier , J E Collins , L K Colman , N R Corby , G J Coville , K M Culley , P Dhami , J Davies , M Dunn , M E Earthrowl , A E Ellington , K A Evans , L Faulkner , M D Francis , A Frankish , J Frankland , L French , P Garner , J Garnett , M J R Ghori , L M Gilby , C J Gillson , R J Glithero , D V Grafham , M Grant , S Gribble , C Griffiths , M Griffiths , R Hall , K S Halls , S Hammond , J L Harley , E A Hart , P D Heath , R Heathcott , S J Holmes , P J Howden , K L Howe , G R Howell , E Huckle , S J Humphray , M D Humphries , A R Hunt , C M Johnson , A A Joy , M Kay , S J Keenan , A M Kimberley , A King , G K Laird , C Langford , S Lawlor , D A Leongamornlert , M Leversha , C R Lloyd , D M Lloyd , J E Loveland , J Lovell , S Martin , M Mashreghi-Mohammadi , G L Maslen , L Matthews , O T McCann , S J McLaren , K McLay , A McMurray , M J F Moore , J C Mullikin , D Niblett , T Nickerson , K L Novik , K Oliver , E K Overton-Larty , A Parker , R Patel , A V Pearce , A I Peck , B Phillimore , S Phillips , R W Plumb , K M Porter , Y Ramsey , S A Ranby , C M Rice , M T Ross , S M Searle , H K Sehra , E Sheridan , C D Skuce , S Smith , M Smith , L Spraggon , S L Squares , C A Steward , N Sycamore , G Tamlyn-Hall , J Tester , A J Theaker , D W Thomas , A Thorpe , A Tracey , A Tromans , B Tubby , M Wall , J M Wallis , A P West , S S White , S L Whitehead , H Whittaker , A Wild , D J Willey , T E Wilmer , J M Wood , P W Wray , J C Wyatt , L Young , R M Younger , D R Bentley , A Coulson , R Durbin , T Hubbard , J E Sulston , I Dunham , J Rogers , S Beck |
2003-10-23 |
GJE1,
SMIM11P1,
TRAPPC3L,
C6orf99,
TOMM6,
HSPD1P16,
MTRNR2L9,
RANBP9,
LOC100505530,
KIF25-AS1,
MICA,
UST,
LOC100996634,
MEI4,
SLC17A2,
CDKN1A,
PRSS16,
CRISP3,
BTN3A3,
BTN2A2,
ECI2,
HMGN4,
SYNCRIP,
UBD,
AGPAT1,
SLC35A1,
SCGN,
DNPH1,
C6orf10,
FARS2,
FUT9,
TBC1D7-LOC100130357,
TRAF3IP2,
HBS1L,
FRS3,
PDE10A,
SMPDL3A,
APOBEC2,
PNRC1,
RAB32,
TRIM31,
KATNA1,
FGFR1OP,
BTN3A2,
BTN3A1,
BTN2A1,
NUDT3,
MRAP2,
RWDD2A,
IL17F,
MTFR2,
STK38,
SFT2D1,
EFHC1,
ZBED9,
MB21D1,
KLHDC3,
NUS1,
GINM1,
IL22RA2,
MAS1L,
TAGAP,
CLIC1,
CCR6,
CNR1,
COL9A1,
COL10A1,
COL11A2,
COL19A1,
COX7A2,
TAAR1,
STXBP5,
NCOA7,
PACRG,
B3GAT2,
SDHAF4,
CD109,
RAET1E,
C6orf141,
HUS1B,
ATF6B,
NRSN1,
MAPK14,
CSNK2B,
CTGF,
ZC2HC1B,
SNRNP48,
MBOAT1,
RNF217,
NKAIN2,
CFAP206,
LINC01600,
BVES-AS1,
CYP21A1P,
DAXX,
CRISP1,
LCA5,
OLIG3,
TXLNB
|
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