| Type | Description |
|---|---|
| Definition | erythrocyte membrane protein 1, PfEMP1 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-12 11:45:00 | All P. falciparum genomes from uncomplicated malaria infections harbor var2csa and also var gene subclasses previously associated with severe malaria. A lack of clustering of VAR2CSA by geography is shown and segments conserved across most var2csa sequences despite high overall sequence diversity at this locus among all samples analyzed are identified. | 28351419 |
| 2016-08-20 10:57:00 | Data suggest that the VAR2CSA variant of PfEMP1 two central DBL domains (DBL3X-DBL4epsilon) contribute to the structuring of the functional VAR2CSA extracellular region. | 26450557 |
| 2014-11-08 10:17:00 | Results show that var2csa encodes the form of PfEMP1 that is expressed specifically in the presence of the placenta through a molecular mechanism that activates translation of the uORF and sequence-specific characteristics of the surrounding transcript. | 23980802 |
| 2012-10-13 11:16:00 | Data indicate that chondroitin sulfate A (CSA)-binding DBL2X domain is situated in the center of the VAR2CSA structure. | 22570492 |
| 2011-08-13 10:41:00 | VAR2CSA is a variant of the PfEMP1 family of adhesion antigens. We present evidence that, in pregnant women, parasites containing multiple var2csa-type genes possess a selective advantage over parasites with a single var2csa gene. | 21592998 |
| Type | IDs |
|---|---|
| Synonymous | PFF0845c |
| Gene |
UniProtKB-ID:
C6KT15_PLAF7
UniprotKB:
C6KT15
UniParc:
UPI0000085691
EMBL:
AL844505
EnsemblGenome:
PF3D7_0617400
KO:
pfa:PF3D7_0617400
|
| Nucleutide sequences |
EMBL-CDS:
CAG24990.1
Gene_ORFName:
PF3D7_0617400
|
| Protein sequencees |
RefSeq:
XP_966160.1
|
| Others |
UniRef100:
UniRef100_W7K9Q4
UniRef90:
UniRef90_W7K9Q4
UniRef50:
UniRef50_W7K9Q4
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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