| Type | Description |
|---|---|
| Definition | lysine methyltransferase 5A |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:51:00 | SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma. | 33127342 |
| 2021-02-02 13:25:00 | SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase. | 31760894 |
| 2021-01-09 13:28:00 | High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression. | 32369110 |
| 2021-01-02 12:49:00 | The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates alpha-tubulin. | 32111740 |
| 2020-05-23 11:53:00 | SET8 deficiency conferred an impaired glucose metabolism phenotype and thus inhibited the progression of hepatocellular carcinoma tumors. By contrast, SET8 overexpression aggravated the glycolytic alterations and tumor progression. Mechanistically, SET8 directly binds to and inactivates KLF4, resulting in suppression of its downstream SIRT4. | 30952833 |
| Type | IDs |
|---|---|
| Synonymous | PR-Set7, PR/SET07, SET07, SET8, SETD8 |
| Gene |
UniProtKB-ID:
KMT5A_HUMAN,
E3VVS3_HUMAN
UniprotKB:
Q9NQR1,
E3VVS3
UniParc:
UPI000002B371,
UPI0001ECF33E,
UPI0000135894
EMBL:
HQ259683,
BC050346,
AY064546,
AK292645,
AY102937,
AF287261
Ensembl:
ENSG00000183955
KO:
hsa:387893
|
| Nucleutide sequences |
EMBL-CDS:
AAH50346.1,
BAF85334.1,
AAL40879.1,
AAM47033.1,
AAF97812.2,
ADP08984.1
Ensembl_TRS:
ENST00000402868
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384629
RefSeq:
NP_001354317.1,
NP_001311434.1,
NP_001311433.1,
NP_065115.3,
NP_001354315.1,
NP_001354318.1,
NP_001311435.1
|
| Others |
UniRef100:
UniRef100_E3VVS3,
UniRef100_Q9NQR1
UniRef90:
UniRef90_Q9NQR1,
UniRef90_H0XZ28
UniRef50:
UniRef50_Q9NQR1
UniGene:
Hs.443735,
Hs.572262
CCDS:
CCDS9247.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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