| Type | Description |
|---|---|
| Definition | Vacuolar protein sorting 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 10:05:00 | Here, the authors show that Vps8 overexpression inhibits homotypic fusion and vacuole protein sorting (HOPS)-dependent trafficking routes including late endosome maturation, autophagosome-lysosome fusion, crinophagy and lysosome-related organelle formation. Mechanistically, Vps8 overexpression abolishes the late endosomal localization of HOPS-specific Vps41/Lt and prevents HOPS assembly. | 31194677 |
| 2017-11-11 10:07:00 | Study shows that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog; Vps8 forms a complex and acts together with Vps16A, Dor/Vps18 and Car/Vps33A, and loss of any of these proteins leads to fragmentation of endosomes. | 27253064 |
| Type | IDs |
|---|---|
| Synonymous | CG10144, Dmel\CG10144, anon-WO0118547.365 |
| Gene |
UniProtKB-ID:
VPS8_DROME
UniprotKB:
Q9VRX2
UniParc:
UPI000007E440
EMBL:
BT088834,
BT053736,
AE014296,
BT100198
EnsemblGenome:
FBgn0035704
KO:
dme:Dmel_CG10144
|
| Nucleutide sequences |
EMBL-CDS:
ACY40032.1,
ACK77654.1,
AAF50660.1,
ACS54286.1
Gene_ORFName:
CG10144
EnsemblGenome_TRS:
FBtr0076986
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0076695
RefSeq:
NP_648048.1
|
| Others |
UniRef100:
UniRef100_Q9VRX2
UniRef90:
UniRef90_Q9VRX2
UniRef50:
UniRef50_Q9VRX2
UniGene:
Dm.15548
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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