| Type | Description |
|---|---|
| Definition | DnaJ-like-1 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 11:36:00 | our data indicate that the MLF/DnaJ-1-dependent increase in Lz level allows the repression of Notch expression and signaling to prevent aberrant blood cell development. Thus our findings establish a functional link between MLF and the co-chaperone DnaJ-1 to control RUNX transcription factor activity and Notch signaling during blood cell development in vivo. | 28742844 |
| 2017-05-20 12:11:00 | Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S | 28158474 |
| 2016-08-20 12:12:00 | Through DnaJ-1, our data connect ataxin-3 and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species. | 26007638 |
| 2016-05-21 11:04:00 | Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A | 25954029 |
| 2014-03-15 11:33:00 | HSP40 and HSP110 function together in protein homeostasis control. | 24091676 |
| Type | IDs |
|---|---|
| Synonymous | CG10578, DNAJ-1, DNAJ1, DROJ1, DmHsp40, Dmel\CG10578, DnaJ1, DnaJ1 64EF, DroJ1, EU3500, HSP40, HSP40/HDJ1, Hdj1, Hsp-40, Hsp40, anon-WO0140519.166, anon-WO0172774.135, dHDJ1, dHDJ1/HSP40, dHdj1, dhdJ1, dhdj-1, dhdj1, dnaJ-1, dnaj-1, droj1, hsp40 |
| Gene |
UniProtKB-ID:
DNAJ1_DROME,
Q53ZT0_DROME
UniprotKB:
Q24133,
Q53ZT0
UniParc:
UPI00000434BF
EMBL:
AY274358,
AY274365,
U34904,
AY274364,
AY274355,
AY274363,
AY274359,
AY274362,
AY274360,
AE014296,
AY274357,
AY274361,
AY058788
EnsemblGenome:
FBgn0263106
KO:
dme:Dmel_CG10578
|
| Nucleutide sequences |
EMBL-CDS:
AAF50753.1,
AAL14017.1,
AAC23584.1,
AAP31285.1,
AAP31281.1,
AAN12104.1,
AAP31288.1,
AAP31283.1,
AAP31282.1,
AAP31284.1,
AAP31286.1,
AAP31280.1,
AAP31278.1,
AAP31287.1
Gene_ORFName:
CG10578,
CG10578,
Dmel_CG10578
EnsemblGenome_TRS:
FBtr0077123,
FBtr0077124,
FBtr0077123,
FBtr0077124
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0076829,
FBpp0076830,
FBpp0076829,
FBpp0076830
RefSeq:
NP_729086.1,
NP_523936.2
|
| Others |
UniRef100:
UniRef100_Q24133
UniRef90:
UniRef90_Q24133
UniRef50:
UniRef50_Q24133
UniGene:
Dm.2839
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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