| Type | Description |
|---|---|
| Definition | kinesin family member C1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:01:00 | The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation. | 33397932 |
| 2020-06-27 11:52:00 | Kifc1 deletion leads to defects in metaphase mitotic spindle assembly, and then results in chromosome structural abnormality. The kifc1(-/-) cells finally form micronuclei in daughter cells, and results in aneuploidy and chromosome loss in cell cycle. | 31127080 |
| 2020-01-25 10:47:00 | Our findings suggest that KIFC1, activated by TCF-4 (TCF7L2), functions as an oncogene and promotes hepatocellular carcinoma (HCC) pathogenesis through regulating HMGA1 transcriptional activity and that KIFC1 is a potential therapeutic target to enhance the paclitaxel sensitivity of HCC | 31340839 |
| 2019-10-05 11:52:00 | KIFC1 was significantly upregulated in bladder cancer (BC) specimens at both the mRNA and protein levels and associated with both shorter cancer-specific survival and recurrence-free survival time. Overexpression of KIFC1 in vitro phosphorylated GSK3beta and promoted Snail through activating AKT to induce proliferation and epithelial-mesenchymal transition and, therefore, substantially promoted BC migration and metasta... | 31278883 |
| 2019-04-27 11:44:00 | Increased levels of KIFC1 were associated with poor prognosis and metastasis in HCC. In addition, KIFC1 induced epithelial-to-mesenchymal transition and HCC metastasis both in vitro and in vivo. KIFC1 was directly regulated by the microRNA miR-532-3p, whose downregulation was associated with metastatic progression in HCC. | 30115976 |
| Type | IDs |
|---|---|
| Synonymous | HSET, KNSL2 |
| Gene |
UniProtKB-ID:
KIFC1_HUMAN,
A0A024RCS7_HUMAN
UniprotKB:
Q9BW19,
A0A024RCS7
UniParc:
UPI000012DDB8
EMBL:
KY500407,
BC121041,
AL050332,
AJ010479,
AL662799,
BX088650,
BC073878,
BC121042,
AL021366,
BX248088,
CH471081,
BC098438,
BC000712,
D14678,
BC063567
Ensembl:
ENSG00000204197,
ENSG00000233450,
ENSG00000237649
KO:
hsa:3833
|
| Nucleutide sequences |
EMBL-CDS:
AAI21043.1,
AAH73878.1,
AAH00712.2,
AAH63567.1,
CAA09217.1,
AAI21042.1,
CAA16157.1,
AAH98438.1,
BAA03509.1,
CAB63782.1,
EAX03728.1,
AQY76894.1,
EAX03727.1
Gene_ORFName:
hCG_17528
Ensembl_TRS:
ENST00000428849,
ENST00000374523,
ENST00000448818
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363647,
ENSP00000407885,
ENSP00000393963
RefSeq:
XP_016866325.1,
NP_002254.2,
XP_011512887.1,
XP_011512889.1,
XP_016866326.1
|
| Others |
UniRef100:
UniRef100_Q9BW19
UniRef90:
UniRef90_Q9BW19
UniRef50:
UniRef50_Q9QWT9
UniGene:
Hs.436912
CCDS:
CCDS34430.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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