| Type | Description |
|---|---|
| Definition | kallikrein B1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 11:55:00 | These results highlight a novel and specific approach to target PKK for the treatment of HAE and other diseases involving contact system activation and overproduction of bradykinin. | 30817230 |
| 2020-05-02 12:16:00 | Plasma high molecular weight kininogen and prekallikrein concentrations were not associated with incident cardiovascular disease. | 31473403 |
| 2019-09-14 13:03:00 | Kallikrein cleaves central complement component C3 directly to yield active components C3b and C3a. The cleavage site within C3 is identical to that recognized by C3 convertase. Kallikrein-generated C3b forms C3 convertases, which trigger C3 amplification loop. Kallikrein-generated C3 convertases are inhibited by factor H; suggesting activation of the contact system locally enhances complement activation on cell surfaces. | 29237166 |
| 2018-11-03 11:53:00 | We further define the interactions of keratinocyte PKK with TP63 and NF-kappaB signaling, highlighting the importance of this protein as a tumor suppressor in skin squamous cell carcinoma development. | 29186361 |
| 2018-06-23 12:02:00 | Plasma kallikrein (PLK)-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer. | 28187111 |
| Type | IDs |
|---|---|
| Synonymous | KLK3, PKK, PKKD, PPK |
| Gene |
UniProtKB-ID:
KLKB1_HUMAN,
B4DMX2_HUMAN,
A8K9A9_HUMAN,
E9PBC5_HUMAN
UniprotKB:
P03952,
B4DMX2,
A8K9A9,
E9PBC5
UniParc:
UPI00015DA991,
UPI000000D8AE,
UPI0001AE7586,
UPI00017A790C
EMBL:
BC117351,
AK292624,
M13143,
AK297672,
AF232740,
AF232741,
AF232738,
AK313378,
AY190920,
CH471056,
AF232737,
AF232739,
AF232736,
BC117349,
AF232734,
AF232742,
AF232735,
AC110771
Ensembl:
ENSG00000164344
KO:
hsa:3818
|
| Nucleutide sequences |
EMBL-CDS:
BAG36176.1,
AAY40900.1,
EAX04623.1,
AAF79940.1,
AAI17352.1,
AAA60153.1,
AAN84794.1,
AAI17350.1,
BAG60034.1,
BAF85313.1
Ensembl_TRS:
ENST00000264690,
ENST00000513864
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264690,
ENSP00000424469
RefSeq:
XP_016863671.1,
XP_011530232.1,
NP_001305323.1,
XP_016863670.1,
XP_016863672.1,
XP_016863673.1,
NP_001305325.1,
NP_000883.2
|
| Others |
UniRef100:
UniRef100_P03952,
UniRef100_B4DMX2,
UniRef100_E9PBC5,
UniRef100_A8K9A9
UniRef90:
UniRef90_A0A2R9CAN4,
UniRef90_P03952,
UniRef90_H0YAC1
UniRef50:
UniRef50_H0V4A7,
UniRef50_P03952
UniGene:
Hs.237642
CCDS:
CCDS34120.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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