| Type | Description |
|---|---|
| Definition | melanoregulin |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 10:50:00 | Mreg contains six alpha helices forming a fishhook-like fold in which positive and negative charges occupy opposite sides of the protein's surface and sandwich a putative, cholesterol recognition sequence (CRAC motif). Mreg containing a point mutation within its CRAC motif still targets to late endosomes/lysosomes, but no longer promotes their microtubule minus end-directed transport. | 30174147 |
| 2016-08-13 11:09:00 | Single membrane POS containing phagosomes recruit endogenous LC3 in an ATG5-dependent manner that is dependent on MREG. In the Mregdsu/dsu RPE, Atg5/12 and LC3 were increased relative to levels in the Mreg+/+ at all time points relative to light onset. | 25301234 |
| 2014-02-01 10:13:00 | This study demonistrated that Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium. | 23611523 |
| 2013-03-16 11:10:00 | The product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of BLOC-2 complex and with ocular albinism in regulating melanosome size. | 22984402 |
| 2013-02-16 12:10:00 | Mreg regulates microtubule-dependent retrograde melanosome transport through the dynein-dynactin motor complex. | 22275436 |
| Type | IDs |
|---|---|
| Synonymous | Gm974, Wdt2, dsu |
| Gene |
UniProtKB-ID:
MREG_MOUSE
UniprotKB:
Q6NVG5
UniParc:
UPI00001E2DFF
EMBL:
BC068125,
AY628210
Ensembl:
ENSMUSG00000039395
KO:
mmu:381269
|
| Nucleutide sequences |
EMBL-CDS:
AAV32092.1,
AAH68125.1
Ensembl_TRS:
ENSMUST00000048860
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041878
RefSeq:
NP_001344417.1,
NP_001005423.1,
XP_006496174.1
|
| Others |
UniRef100:
UniRef100_Q6NVG5
UniRef90:
UniRef90_Q6NVG5
UniRef50:
UniRef50_Q6NVG5
UniGene:
Mm.422636
CCDS:
CCDS15032.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员