| Type | Description |
|---|---|
| Definition | melanoregulin |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 10:50:00 | Mreg contains six alpha helices forming a fishhook-like fold in which positive and negative charges occupy opposite sides of the protein's surface and sandwich a putative, cholesterol recognition sequence (CRAC motif). Mreg containing a point mutation within its CRAC motif still targets to late endosomes/lysosomes, but no longer promotes their microtubule minus end-directed transport. | 30174147 |
| 2016-08-13 11:09:00 | Single membrane POS containing phagosomes recruit endogenous LC3 in an ATG5-dependent manner that is dependent on MREG. In the Mregdsu/dsu RPE, Atg5/12 and LC3 were increased relative to levels in the Mreg+/+ at all time points relative to light onset. | 25301234 |
| 2014-02-01 10:13:00 | This study demonistrated that Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium. | 23611523 |
| 2013-03-16 11:10:00 | The product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of BLOC-2 complex and with ocular albinism in regulating melanosome size. | 22984402 |
| 2013-02-16 12:10:00 | Mreg regulates microtubule-dependent retrograde melanosome transport through the dynein-dynactin motor complex. | 22275436 |
| Type | IDs |
|---|---|
| Synonymous | Gm974, Wdt2, dsu |
| Gene |
UniProtKB-ID:
MREG_MOUSE
UniprotKB:
Q6NVG5
UniParc:
UPI00001E2DFF
EMBL:
BC068125,
AY628210
Ensembl:
ENSMUSG00000039395
KO:
mmu:381269
|
| Nucleutide sequences |
EMBL-CDS:
AAV32092.1,
AAH68125.1
Ensembl_TRS:
ENSMUST00000048860
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041878
RefSeq:
NP_001344417.1,
NP_001005423.1,
XP_006496174.1
|
| Others |
UniRef100:
UniRef100_Q6NVG5
UniRef90:
UniRef90_Q6NVG5
UniRef50:
UniRef50_Q6NVG5
UniGene:
Mm.422636
CCDS:
CCDS15032.1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
University of Pennsylvania |
5 |
| 2 |
and Blood Institute |
2 |
| 3 |
Institute of Developmental Genetics |
2 |
| 4 |
Institute of Molecular Embryology and Genetics |
2 |
| 5 |
Case Western Reserve University School of Medicine and Center for Human Genetics |
1 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
Kathleen Boesze-Battaglia |
6 |
| 2 |
K J Moore |
4 |
| 3 |
N G Copeland |
4 |
| 4 |
D A Swing |
4 |
| 5 |
N A Jenkins |
4 |