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3812 KIR3DL2

3812

KIR3DL2

killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

研究结论

Date Results Publications
2019-11-02 11:46:00 Study found that KIR3DL2 is expressed in tissue tumor-infiltrating cells in the majority of patients with adult T-cell lymphoma/leukemia. Disease-specific survival of patients with KIR3DL2 expression > 50% was statistically significantly decreased compared with patients with KIR3DL2 expression < 5% or KIR3DL2 expression between 5% and 50%. 29315492
2018-06-02 10:40:00 We show that KIR3DL2 expression is the most sensitive diagnostic criterion of Sezary syndrome when compared with all other available biological criteria. KIR3DL2 therefore represents a valuable tool for routine use as a clinical parameter at diagnosis, for prognosis and during patient follow-up 28119365
2018-01-27 10:11:00 results identified significant KIR3DL2 expression in all cutaneous T-cell lymphomas subtypes 29089310
2016-08-27 10:20:00 Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death 26928464
2016-08-20 11:34:00 KIR-3DL2 binding to HLA-B27 licenses Th17 cell differentiation in spondyloarthritis. 26841353

名称对应

Type IDs
Synonymous 3DL2, CD158K, KIR-3DL2, NKAT-4, NKAT4, NKAT4B, p140
Gene
UniProtKB-ID: KI3L2_HUMAN, Q8NHK6_HUMAN, Q8NHI6_HUMAN, A0A0U1WNF3_HUMAN
UniprotKB: P43630, Q8NHK6, Q8NHI6, A0A0U1WNF3
UniParc: UPI000013D888, UPI000006DB64, UPI0000071FF0, UPI000012DB25
EMBL: LN649144, X93596, MN167513, L76665, X93595, KJ535483, MN167520, AY789068, U30272, LN999797, AY059418, X94374, LN650688, GU182340, MN167512, L76666, GU182338, LN999789, KP420437, AY789067, AF263617, MN167514, KJ535482, MN167524, L41270, X94373
Ensembl: ENSG00000283951, ENSG00000284381, ENSG00000276004, ENSG00000240403, ENSG00000276357, ENSG00000277181, ENSG00000278809, ENSG00000278442, ENSG00000276739, ENSG00000274722, ENSG00000275083, ENSG00000278474, ENSG00000278361, ENSG00000284213, ENSG00000278710, ENSG00000283975, ENSG00000275626, ENSG00000284063, ENSG00000275566, ENSG00000275416, ENSG00000275629
KO: hsa:3812
Nucleutide sequences
EMBL-CDS: CAA63792.1, AAB36593.1, AAX23112.1, CAA63791.1, CAA64151.1, AAB52520.1, AAB36594.1, AAA69871.1, CAA64150.1, AAX23113.1, CUX91181.1, AJI80984.3, AAK30062.1, AAL27093.1, CUX91189.1, AIF79781.1, QKY12275.1, QKY12363.1, QKY12268.1, AIF79782.1, QKY12333.1, CEI24328.1, CEI74440.1, QKY12261.1
Ensembl_TRS: ENST00000638726, ENST00000639313, ENST00000639252, ENST00000638805, ENST00000638891, ENST00000638970, ENST00000612138, ENST00000613612, ENST00000640782, ENST00000617957, ENST00000622024, ENST00000618273, ENST00000614753, ENST00000611608, ENST00000619683, ENST00000620817, ENST00000617666, ENST00000622453, ENST00000613610, ENST00000622579, ENST00000270442, ENST00000611859, ENST00000617481, ENST00000617354, ENST00000638330, ENST00000611628, ENST00000326321, ENST00000621155, ENST00000616438, ENST00000640359, ENST00000621701
Protein sequencees
Ensembl_PRO: ENSP00000481209, ENSP00000491248, ENSP00000270442, ENSP00000482301, ENSP00000491183, ENSP00000481306, ENSP00000491303, ENSP00000478251, ENSP00000482655, ENSP00000482110, ENSP00000491436, ENSP00000481871, ENSP00000492880, ENSP00000479425, ENSP00000491707, ENSP00000481579, ENSP00000479903, ENSP00000479299, ENSP00000482589, ENSP00000479772, ENSP00000480578, ENSP00000325525, ENSP00000481662, ENSP00000477519, ENSP00000477516, ENSP00000492261, ENSP00000492117, ENSP00000482565, ENSP00000481911, ENSP00000484518, ENSP00000490992
RefSeq: NP_006728.2, XP_016882273.1, NP_001229796.1, XP_011525242.1
Others
UniRef100: UniRef100_A0A0G2JPQ5, UniRef100_Q8NHK6, UniRef100_P43630
UniRef90: UniRef90_P43630
UniRef50: UniRef50_P43629
UniGene: Hs.645228, Hs.645532, Hs.654605
CCDS: CCDS58677.1, CCDS12906.1

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