| Type | Description |
|---|---|
| Definition | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:58:00 | Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population. | 32422377 |
| 2020-07-18 11:05:00 | In head and neck squamous cell carcinoma (HNSCC), KIR2DL2 is positively while KIR2DS4 is negatively associated with advanced stage. The higher proportion of LNM in carriers of KIR2DL2 and carriers of 5 iKIRs, suggested that inhibitory KIRs are associated with metastatic risk | 31751561 |
| 2020-04-11 11:25:00 | KIR2DS4 has a strong preference for rare peptides carrying a Trp at position 8 (p8) of 9-mer peptides bound to HLA-C*05:01. The complex of a peptide bound to HLA-C*05:01 with a Trp at p8 was sufficient for activation of primary KIR2DS4+ NK cells, independent of activation by other receptors and of prior NK cell licensing. Study predicts that over 1,000 bacterial species could activate NK cells through KIR2DS4. | 31138701 |
| 2019-11-02 10:32:00 | The higher frequencies of KIR3DS1-Bw4 and homozygotic KIR2DS4- in patients compared with controls suggest they confer susceptibility to polycystic ovary syndrome. A lower frequency of KIR2DS4-full was observed in patients. | 30099219 |
| 2019-02-02 10:38:00 | Promoter methylation decreased and gene expression increased for KIR2DS4 after acute exercise. Chronic exercise resulted in a minor decrease of DNA methylation and did not alter gene expression. | 30508863 |
| Type | IDs |
|---|---|
| Synonymous | CD158I, KIR-2DS4, KIR1D, KIR412, KKA3, NKAT-8, NKAT8 |
| Gene |
UniProtKB-ID:
KI2S4_HUMAN,
A0A0C4ZN05_HUMAN,
Q8NHJ0_HUMAN,
A0A1W2PR63_HUMAN,
Q86VI6_HUMAN,
A0A0C4ZN30_HUMAN
UniprotKB:
P43632,
A0A0C4ZN05,
Q8NHJ0,
A0A1W2PR63,
Q86VI6,
A0A0C4ZN30
UniParc:
UPI000012DB22,
UPI00000726F5,
UPI0000366E84,
UPI000013EC99,
UPI000018F5E3
EMBL:
U24077,
MN167514,
KP025962,
KU842452,
MN167524,
BC103693,
EU143323,
BC101977,
KP420442,
AY366245,
AJ417554,
KP420446,
KP420437,
CU464062,
MN167512,
MN167526,
CU464060,
MN167520,
AY102623,
L76671,
MN167523,
X94609,
KP420444,
LT630485,
AF002255,
MN167522,
MN167513
Ensembl:
ENSG00000275353,
ENSG00000276395,
ENSG00000276154,
ENSG00000283882,
ENSG00000275731,
ENSG00000284264,
ENSG00000274406,
ENSG00000276885,
ENSG00000283870,
ENSG00000274921,
ENSG00000276634,
ENSG00000274947,
ENSG00000284244,
ENSG00000274957
KO:
hsa:3809
|
| Nucleutide sequences |
EMBL-CDS:
AAI03694.1,
AAC50336.1,
AAR16203.1,
AAB61281.1,
AAI01978.1,
AAB36599.1,
CAA64317.1,
QKY12332.1,
AJI81022.1,
AJN00743.1,
QKY12355.1,
QKY12260.1,
AJI81046.1,
AJI80983.1,
QKY12274.1,
SHO29794.1,
QKY12362.1,
QKY12383.1,
QKY12348.1,
ABX52408.1,
CAD10378.1,
AAM52329.1,
AJI81033.1,
ANJ04816.1,
QKY12267.1
Ensembl_TRS:
ENST00000620669,
ENST00000644051,
ENST00000619771,
ENST00000613654,
ENST00000617469,
ENST00000617825,
ENST00000612783,
ENST00000611311,
ENST00000644154,
ENST00000642862,
ENST00000638566,
ENST00000621436,
ENST00000640817,
ENST00000640941,
ENST00000614639,
ENST00000640257,
ENST00000617550
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000491676,
ENSP00000478241,
ENSP00000481319,
ENSP00000494670,
ENSP00000477744,
ENSP00000481753,
ENSP00000494622,
ENSP00000492546,
ENSP00000484123,
ENSP00000479843,
ENSP00000483112,
ENSP00000495680,
ENSP00000483274,
ENSP00000480062,
ENSP00000492248,
ENSP00000492337,
ENSP00000479749
RefSeq:
NP_036446.3,
NP_001268901.1,
NP_001268900.1
|
| Others |
UniRef100:
UniRef100_P43632,
UniRef100_A0A0C4ZN30,
UniRef100_A0A1W2PR63,
UniRef100_Q86VI6
UniRef90:
UniRef90_A0A1W2PR63,
UniRef90_P43632
UniRef50:
UniRef50_A0A1W2PR63,
UniRef50_P43628-2
UniGene:
Hs.654608
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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