| Type | Description |
|---|---|
| Definition | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:38:00 | Skeletal muscle-specific Obsl1 knockouts show a benign phenotype similar to obscurin knockouts. Only deletion of both proteins and removal of their functional redundancy revealed their roles for sarcolemmal stability and sarcoplasmic reticulum organization. | 31098411 |
| 2018-05-19 11:15:00 | These findings implicate small obscurins in the maintenance of cardiomyocyte size and coupling. | 28826662 |
| 2017-06-10 10:13:00 | Altogether, these results suggest that obscurin is required for the maintenance of morphological and ultrastructural integrity of skeletal muscle fibers against damage induced by intense mechanical stress and point to the diaphragm as the skeletal muscle most severely affected in obscurin-deficient mice. | 27784675 |
| 2015-01-17 10:59:00 | obscurins are not restricted to striated muscles, but are abundantly expressed in several tissues and organs including brain, skin, kidney, liver, spleen, and lung. | 24516603 |
| 2013-07-06 11:49:00 | the obscurin kinase domains, SK1 and SK2, are active enzymes with distinct substrate specificities. | 23392350 |
| Type | IDs |
|---|---|
| Synonymous | BC046431, Gm878, UNC89 |
| Gene |
UniProtKB-ID:
H7BX05_MOUSE,
E9QQ96_MOUSE
UniprotKB:
H7BX05,
E9QQ96
UniParc:
UPI00022580FF,
UPI0002258100
EMBL:
AL662809,
AL645854
Ensembl:
ENSMUSG00000061462
KO:
mmu:380698
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000047441,
ENSMUST00000052872
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000038264,
ENSMUSP00000049737
RefSeq:
NP_001164983.2,
NP_954603.3
|
| Others |
UniRef100:
UniRef100_E9QQ96,
UniRef100_H7BX05
UniRef90:
UniRef90_A0A0G2JUP3,
UniRef90_A0A0G2K8N1
UniRef50:
UniRef50_A0A0G2K8N1,
UniRef50_A0A0G2K3P4
UniGene:
Mm.339542
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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