| Type | Description |
|---|---|
| Definition | LEM domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2014-01-18 11:10:00 | a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A. | 23779087 |
| 2010-06-14 12:06:00 | the heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome. | 19862465 |
| 2010-01-21 00:00:00 | The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac. | 17329363 |
| 2010-01-21 00:00:00 | In Man1-deficient embryos, the expression of Tgfb1 is upregulated and Smad2/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis. | 16943282 |
| 2010-01-21 00:00:00 | Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner | 18697220 |
| Type | IDs |
|---|---|
| Synonymous | AI316861, Man1 |
| Gene |
UniProtKB-ID:
MAN1_MOUSE,
E9QP59_MOUSE
UniprotKB:
Q9WU40,
E9QP59
UniParc:
UPI0001565457,
UPI0001505BA2,
UPI0001565458
EMBL:
AC140381,
AF112300,
BC082610,
AK140538
Ensembl:
ENSMUSG00000048661
KO:
mmu:380664
|
| Nucleutide sequences |
EMBL-CDS:
AAD31594.1,
BAE24418.1
Ensembl_TRS:
ENSMUST00000119944
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000113103
RefSeq:
NP_001074662.2
|
| Others |
UniRef100:
UniRef100_E9QP59,
UniRef100_Q9WU40
UniRef90:
UniRef90_Q9WU40
UniRef50:
UniRef50_Q9Y2U8
UniGene:
Mm.339371
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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