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3795 KHK

3795

KHK

ketohexokinase

protein-coding

Homo sapiens

基因描述

Type Description
Definition ketohexokinase

研究结论

Date Results Publications
2020-11-21 13:19:00 Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. 33116123
2020-05-30 12:34:00 KHK-A has a role in antioxidative stress and hepatocellular carcinoma development that involves phosphorylating p62 31032410
2017-12-16 12:11:00 Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft. 28954733
2017-07-22 14:07:00 Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. 27322374
2017-06-03 10:20:00 compared with normal hepatocytes, hepatocellular carcinoma (HCC) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc-dependent and heterogeneous nuclear ribonucleoprotein (hnRNP) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform. 27088854

名称对应

Type IDs
Gene
UniProtKB-ID: KHK_HUMAN, A0A140VJM6_HUMAN
UniprotKB: P50053, A0A140VJM6
UniParc: UPI000002ACC0, UPI000012DE02
EMBL: Y09336, BC006233, AJ005168, Y09341, Y09340, AC013403, HM005415, CR456801, X78678, CH471053, X78677
Ensembl: ENSG00000138030
KO: hsa:3795
Nucleutide sequences
EMBL-CDS: CAA70522.1, CAA70523.1, CAA06409.1, CAA70516.1, AAX93167.1, AAH06233.1, CAA55346.1, EAX00643.1, CAA55347.1, CAA70521.1, CAG33082.1, AEE61013.1
Ensembl_TRS: ENST00000260599, ENST00000260598
Protein sequencees
Ensembl_PRO: ENSP00000260598, ENSP00000260599
RefSeq: NP_000212.1, XP_006712076.1, XP_006712074.1, XP_005264351.1, XP_006712071.1, XP_005264355.1, XP_016859550.1, XP_006712072.1, XP_016859549.1, XP_006712077.1, XP_006712075.1, XP_006712073.1, XP_005264353.1, NP_006479.1
Others
UniRef100: UniRef100_P50053, UniRef100_A0A140VJM6
UniRef90: UniRef90_P50053, UniRef90_Q5RD71
UniRef50: UniRef50_P50053, UniRef50_P97328
UniGene: Hs.567297
CCDS: CCDS1734.1, CCDS1735.1

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