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37949 Mmp1

37949

Mmp1

Matrix metalloproteinase 1

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition Matrix metalloproteinase 1

研究结论

Date Results Publications
2020-03-14 12:10:00 Matrix metalloproteinase 1 (MMP1) is required in tracheal cells for normal invasion speed and for the dynamic organization of growth-cone-like branch tips. MMP1 remodels the CollagenIV-containing matrix around branch tips, which show differential matrix composition with low CollagenIV levels, while Laminin is present along tracheal branches. 31577228
2018-11-17 12:19:00 there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family 28300207
2018-08-04 11:19:00 results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation. 29853618
2018-05-05 11:13:00 This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons. 28825401
2017-12-09 10:52:00 Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent. 28696218

名称对应

Type IDs
Synonymous CG4859, Dm1-MMP, Dmel\CG4859, MMP-1, MMP1, MMp1, Mmp 1, dMMP1, dm1-MMP, dmmp1, l(2)k04809, mmp1
Gene
UniProtKB-ID: Q8MLN6_DROME, A0A0B4K7H5_DROME, A0A0B4JD53_DROME, Q9W122_DROME, A0A0B4JCU7_DROME, A0A0B4JDA7_DROME
UniprotKB: Q8MLN6, A0A0B4K7H5, A0A0B4JD53, Q9W122, A0A0B4JCU7, A0A0B4JDA7
UniParc: UPI0001F770D8, UPI0000082B9B, UPI0001F770D7, UPI0001F770DC, UPI0001F770D9, UPI000191489F
EMBL: AE013599, AY118405, BT021303
EnsemblGenome: FBgn0035049
KO: dme:Dmel_CG4859
Nucleutide sequences
EMBL-CDS: ADV37246.1, ADV37247.1, AAM68327.2, AFH08252.1, ADV37250.1, ADV37249.1, ADV37251.1, AAM48434.1, AAF47255.3, AAX33451.1, ADV37245.1, ADV37248.1
Gene_ORFName: CG4859, Dmel_CG4859, Dmel_CG4859, CG4859, Dmel_CG4859, CG4859, CG4859, Dmel_CG4859, CG4859, Dmel_CG4859, Dmel_CG4859, CG4859
EnsemblGenome_TRS: FBtr0304007, FBtr0304006, FBtr0273264, FBtr0306656, FBtr0304010, FBtr0304009, FBtr0304011, FBtr0273263, FBtr0304005, FBtr0304008
Protein sequencees
EnsemblGenome_PRO: FBpp0292975, FBpp0292976, FBpp0271772, FBpp0297611, FBpp0292979, FBpp0292978, FBpp0292980, FBpp0271771, FBpp0292974, FBpp0292977
RefSeq: NP_001189004.1, NP_523852.3, NP_001188999.1, NP_001246499.1, NP_001189005.1, NP_001189003.1, NP_001189000.1, NP_726473.2, NP_001189002.1, NP_001189001.1
Others
UniRef100: UniRef100_B5X0I8, UniRef100_A0A0B4JCU7, UniRef100_Q8MLN6, UniRef100_A0A0B4JD53, UniRef100_A0A0B4JDA7, UniRef100_A0A0B4K7H5
UniRef90: UniRef90_A0A0B4JDA7, UniRef90_A0A0B4JCU7
UniRef50: UniRef50_A0A0B4JCU7
UniGene: Dm.19999

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