| Type | Description |
|---|---|
| Definition | NHL repeat containing E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:10:00 | Laforin/malin complex interacts physically and co-localizes intracellularly with core components of the PI3KC3 complex (Beclin1, Vps34 and Vps15), and that this interaction is specific and results in the polyubiquitination of these proteins. | 31758957 |
| 2016-09-17 11:23:00 | Malin promotes its own degradation via auto-ubiquitination.Malin preferentially degrades the phosphatase-inactive laforin monomer. | 26648032 |
| 2016-01-30 11:45:00 | laforin/malin complex is able to interact with and ubiquitinate both PKM1 and PKM2 | 26493215 |
| 2015-10-03 11:19:00 | Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway. | 26102034 |
| 2015-03-07 12:27:00 | This study demonistrated that NHLRC1 mutations were detected in some case of Mild Lafora disease patients. | 25270369 |
| Type | IDs |
|---|---|
| Synonymous | EPM2A, EPM2B, MALIN, bA204B7.2 |
| Gene |
UniProtKB-ID:
NHLC1_HUMAN
UniprotKB:
Q6VVB1
UniParc:
UPI0000198CE1
EMBL:
BC103890,
BK001510,
AL589723,
BC103889,
AY324850,
BC103888
Ensembl:
ENSG00000187566
KO:
hsa:378884
|
| Nucleutide sequences |
EMBL-CDS:
AAQ19671.1,
DAA01954.1,
AAI03891.1,
AAI03890.1,
AAI03889.1
Ensembl_TRS:
ENST00000340650
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000345464
RefSeq:
NP_940988.2
|
| Others |
UniRef100:
UniRef100_Q6VVB1
UniRef90:
UniRef90_Q6VVB1
UniRef50:
UniRef50_Q6VVB1
UniGene:
Hs.348351
CCDS:
CCDS4542.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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