| Type | Description |
|---|---|
| Definition | centromere protein S |
| Date | Results | Publications |
|---|---|---|
| 2015-10-31 11:32:00 | MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage. | 24390579 |
| 2014-12-27 13:59:00 | The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA. | 24699063 |
| 2014-09-13 12:01:00 | CENP-S is not found in a soluble complex with its binding partner CENP-T but it interacts strongly and specifically with immobilized CENP-T in an in vivo binding assay. | 24522885 |
| 2014-08-30 11:19:00 | It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins. | 24256282 |
| 2013-11-16 11:54:00 | A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin. | 23886707 |
| Type | IDs |
|---|---|
| Synonymous | APITD1, CENP-S, FAAP16, MHF1 |
| Gene |
UniProtKB-ID:
CENPS_HUMAN
UniprotKB:
Q8N2Z9
UniParc:
UPI000006DA6A,
UPI000006CFC2,
UPI000007101C
EMBL:
AF516753,
AL139424,
AL354956,
BC029430,
AF521016
Ensembl:
ENSG00000175279
KO:
hsa:378708,
hsa:100526739
|
| Nucleutide sequences |
EMBL-CDS:
AAH29430.1,
AAM61954.1,
AAM70482.1
Ensembl_TRS:
ENST00000309048
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000308583
RefSeq:
NP_954988.1
|
| Others |
UniRef100:
UniRef100_Q8N2Z9
UniRef90:
UniRef90_Q8N2Z9
UniRef50:
UniRef50_Q8N2Z9
UniGene:
Hs.412311
CCDS:
CCDS115.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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