| Type | Description |
|---|---|
| Definition | NLR family, pyrin domain containing 12 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:33:00 | NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation. | 32632939 |
| 2020-10-24 13:57:00 | NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease. | 31367214 |
| 2020-02-29 10:29:00 | Nlrp12(-/-) mice were highly susceptible to diethylnitrosamine-induced hepatocellular carcinoma with increased inflammation, hepatocyte proliferation, and tumor burden. Consistently, Nlrp12(-/-) tumors showed higher expression of proto-oncogenes cJun and cMyc and downregulation of tumor suppressor p21. | 30990169 |
| 2020-02-01 10:44:00 | NLRP12 downregulates the inflammatory cytokine and antimicrobial molecule production in macrophages. | 31292668 |
| 2019-12-07 10:24:00 | NRP12 reduced the severity of P. aeruginosa keratitis by inhibiting corneal inflammation and enhancing bacterial killing. | 30556841 |
| Type | IDs |
|---|---|
| Synonymous | Nalp12, PYPAF7, monarch-1 |
| Gene |
UniProtKB-ID:
NAL12_MOUSE
UniprotKB:
E9Q5R7
UniParc:
UPI0000D684CC
EMBL:
AK149454,
CAAA01093162,
CAAA01093166,
CAAA01193276
Ensembl:
ENSMUSG00000097297,
ENSMUSG00000078817
KO:
mmu:378425
|
| Nucleutide sequences |
EMBL-CDS:
BAE28888.1
Ensembl_TRS:
ENSMUST00000181320,
ENSMUST00000108653
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000104293,
ENSMUSP00000137758
RefSeq:
NP_001028603.1,
XP_006540194.1,
XP_017177810.1
|
| Others |
UniRef100:
UniRef100_E9Q5R7
UniRef90:
UniRef90_E9Q5R7
UniRef50:
UniRef50_P59046
UniGene:
Mm.277152
CCDS:
CCDS51963.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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