| Type | Description |
|---|---|
| Definition | potassium calcium-activated channel subfamily N member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:19:00 | In KCNN4-related disease, the main symptoms were more severe anemia, hemolysis and iron overload, with no clear sign of red cell dehydration; therefore, this disorder would be better described as a 'Gardos channelopathy'. | 30655378 |
| 2020-06-06 12:14:00 | High KCa3.1 Expression is associated with Active Ulcerative Colitis. | 31141130 |
| 2020-03-28 10:06:00 | Chronic KCNN4-driven red cell dehydration and intracellular cation imbalance can lead to reduced KCNN4 activity in hereditary xerocytosis and wild type red cells. | 31091145 |
| 2019-12-14 12:25:00 | Data demonstrate that IKCa and SK1 subunits prefer to form heteromeric channels when coexpressed in a heterologous system that will alter their responsiveness to pharmacological tools typically used to define their expression pattern. | 31048549 |
| 2019-11-02 11:32:00 | Study found that the expression of KCa3.1 was significantly elevated in poorly differentiated hepatocellular carcinoma (HCC) tissues and could promote cell proliferation, migration, and invasion. Mechanistically, KCa3.1 promoted cell cycle progression and migration and invasion of HCC cells by SKP2 to trigger the degradation of p21 and p27 and targeting RELN to induce epithelial-mesenchymal transition. | 30628729 |
| Type | IDs |
|---|---|
| Synonymous | DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4 |
| Gene |
UniProtKB-ID:
KCNN4_HUMAN
UniprotKB:
O15554
UniParc:
UPI0000000DF3
EMBL:
AF053403,
BT007426,
AF000972,
AF395661,
AF305733,
AF305731,
CH471126,
AF022797,
BC015337,
AF305732,
AF305735,
AF033021,
AF305734,
AF022150
Ensembl:
ENSG00000104783
KO:
hsa:3783
|
| Nucleutide sequences |
EMBL-CDS:
AAP36094.1,
AAC36804.1,
AAB82739.1,
AAC51913.1,
AAC23541.1,
AAH15337.1,
AAC35281.1,
AAG26917.1,
EAW57230.1,
AAK81862.1
Ensembl_TRS:
ENST00000648319
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000496939
RefSeq:
XP_005258939.1,
NP_002241.1,
XP_005258940.1
|
| Others |
UniRef100:
UniRef100_O15554
UniRef90:
UniRef90_O15554
UniRef50:
UniRef50_O15554
UniGene:
Hs.10082
CCDS:
CCDS12630.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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