| Type | Description |
|---|---|
| Definition | egalitarian |
| Date | Results | Publications |
|---|---|---|
| 2019-03-30 10:07:00 | artificially dimerized Egl activates dynein-dynactin-BicD in the absence of mRNA. The ability of mRNA cargo to orchestrate the activation of the mRNP (messenger ribonucleotide protein) complex is an elegant way to ensure that only cargo-bound motors are motile. | 29944116 |
| 2019-03-30 10:07:00 | the RNA is required for robust activation of dynein motility. We show that a cis-acting RNA localisation signal promotes the interaction of Egl with BicD, which licenses the latter protein to recruit dynein and dynactin. Our data support a model for BicD activation based on RNA-induced occupancy of two Egl-binding sites on the BicD dimer. | 29944118 |
| 2019-02-09 11:59:00 | following germline piRNA depletion, abundant maternal HeT-A RNP interacts with Egl resulting in ectopic accumulation of Egl close to the centrosomes during the syncytial stage of embryogenesis; findings suggest that its abnormal localization likely leads to impaired embryonic axis specification typical for piRNA pathway mutants | 30157274 |
| 2017-05-06 11:22:00 | In the absence of Egl function, oocyte microtubules completely fail to reorganize. Egl also appears to function in regulating the translation of critical polarity determining mRNAs. | 27017624 |
| 2010-01-21 00:00:00 | Egl interacts directly with dynein light chain, a microtubule motor component, through an Egl domain distinct from that which binds BicD; data provide a direct link between a molecule necessary for oocyte specification and the microtubule motor complex | 15077115 |
| Type | IDs |
|---|---|
| Synonymous | CG4051, Dmel\CG4051, EGL, Egl, egal |
| Gene |
UniProtKB-ID:
Q9W1K4_DROME
UniprotKB:
Q9W1K4
UniParc:
UPI0000228564
EMBL:
AE013599
EnsemblGenome:
FBgn0000562
KO:
dme:Dmel_CG4051
|
| Nucleutide sequences |
EMBL-CDS:
AHN56574.1,
AAF47054.4
Gene_ORFName:
Dmel_CG4051,
CG4051
EnsemblGenome_TRS:
FBtr0114586,
FBtr0343272
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0113078,
FBpp0309937
RefSeq:
NP_726360.3,
NP_001286779.1
|
| Others |
UniRef100:
UniRef100_Q9W1K4
UniRef90:
UniRef90_Q9W1K4
UniRef50:
UniRef50_Q9W1K4
UniGene:
Dm.6350
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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