| Type | Description |
|---|---|
| Definition | leucine rich repeat containing 10 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 11:25:00 | Examination of a patient with dilated cardiomyopathy revealed homozygosity for a previously unreported LRRC10 variant: I195T. Wild-type and I195T LRRC10 function as cardiac-specific subunits of L-type Ca(2+) channels and exert dramatically different effects on channel gating, providing a potential link to DCM. | 29431102 |
| 2017-11-04 11:35:00 | LRRC10 may be a new susceptible gene for Sudden unexplained nocturnal death syndrome, and LRRC10 variant was initially and genetically linked to Brugada syndrome associated arrhythmia. | 28032242 |
| 2016-05-14 11:28:00 | This study firstly reports the association of LRRC10 mutations with enhanced susceptibility to dilated cardiomyopathy in humans. | 26017719 |
| Type | IDs |
|---|---|
| Synonymous | HRLRRP, LRRC10A |
| Gene |
UniProtKB-ID:
LRC10_HUMAN
UniprotKB:
Q5BKY1
UniParc:
UPI00001D79A1
EMBL:
BC090881,
AK123908
Ensembl:
ENSG00000198812
KO:
hsa:376132
|
| Nucleutide sequences |
EMBL-CDS:
AAH90881.1,
BAC85724.1
Ensembl_TRS:
ENST00000361484
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355166
RefSeq:
NP_963844.2
|
| Others |
UniRef100:
UniRef100_Q5BKY1
UniRef90:
UniRef90_Q5BKY1
UniRef50:
UniRef50_Q5BKY1
UniGene:
Hs.448708
CCDS:
CCDS31856.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 33001583 |
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Thorac Cancer Chun-Guo Mao , Sha-Sha Jiang , Cheng Shen , Tan Long , Hua Jin , Qun-You Tan , Bo Deng |
2020-11-01 | - |
| 29431102 |
J Am Heart Assoc Marites T Woon , Pamela A Long , Louise Reilly , Jared M Evans , Alexis M Keefe , Martin R Lea , Carl J Beglinger , Ravi C Balijepalli , Youngsook Lee , Timothy M Olson , Timothy J Kamp |
2018-02-03 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28032242 |
Int. J. Legal Med. Lei Huang , Shuangbo Tang , Yili Chen , Liyong Zhang , Kun Yin , Yeda Wu , Jinxiang Zheng , Qiuping Wu , Jonathan C Makielski , Jianding Cheng |
2017-05-01 | - |
| 26608339 |
LRRC10 is required to maintain cardiac function in response to pressure overload. Am J Physiol Heart Circ Physiol Matthew J Brody , Li Feng , Adrian C Grimes , Timothy A Hacker , Timothy M Olson , Timothy J Kamp , Ravi C Balijepalli , Youngsook Lee |
2016-01-15 | - |
| 26017719 |
Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy. Mol Med Rep Xin-Kai Qu , Fang Yuan , Ruo-Gu Li , Lei Xu , Wei-Feng Jing , Hua Liu , Ying-Jia Xu , Min Zhang , Xu Liu , Wei-Yi Fang , Yi-Qing Yang , Xing-Biao Qiu |
2015-09-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 19490893 |
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell Ji Luo , Michael J Emanuele , Danan Li , Chad J Creighton , Michael R Schlabach , Thomas F Westbrook , Kwok-Kin Wong , Stephen J Elledge |
2009-05-29 | - |
| 18391951 |
Many sequence variants affecting diversity of adult human height. Nat. Genet. Daniel F Gudbjartsson , G Bragi Walters , Gudmar Thorleifsson , Hreinn Stefansson , Bjarni V Halldorsson , Pasha Zusmanovich , Patrick Sulem , Steinunn Thorlacius , Arnaldur Gylfason , Stacy Steinberg , Anna Helgadottir , Andres Ingason , Valgerdur Steinthorsdottir , Elinborg J Olafsdottir , Gudridur H Olafsdottir , Thorvaldur Jonsson , Knut Borch-Johnsen , Torben Hansen , Gitte Andersen , Torben Jorgensen , Oluf Pedersen , Katja K Aben , J Alfred Witjes , Dorine W Swinkels , Martin den Heijer , Barbara Franke , Andre L M Verbeek , Diane M Becker , Lisa R Yanek , Lewis C Becker , Laufey Tryggvadottir , Thorunn Rafnar , Jeffrey Gulcher , Lambertus A Kiemeney , Augustine Kong , Unnur Thorsteinsdottir , Kari Stefansson |
2008-05-01 |
LOC100129340,
C5orf66,
CDK6,
DCAF7,
SF3B4,
CAP2,
FBLN5,
CCT2,
FRS2,
MMP24,
MTMR11,
ADCY3,
SPIN1,
CPSF6,
BVES,
CEP250,
TSEN15,
DIS3L2,
CRYBA2,
SLC23A3,
RASGEF1B,
SAMD3,
ADAMTS17,
DNMT3A,
DTNB,
SDR16C5,
ETV6,
DLEU7,
EFEMP1,
SCUBE3,
EFR3B,
ANKS1A,
CDK20,
ZBTB38,
LCORL,
DNM3,
GOLIM4,
GNA12,
GNAZ,
SLCO1B3,
OR2Z1,
PPIL6,
MRPL42,
HMGA1,
NACA2,
CATSPER3,
IGLL1,
IHH,
EIF6,
LRRC10,
CENPW,
HIST1H2APS3,
LIN28B,
LYN,
LYZ,
MAP3K3,
ATXN3,
MOS,
MT1F,
MYO1F,
NPPC,
DEF6,
DNAJC27,
CRLF3,
PDE3A,
PDE6D,
PENK,
PEX1,
SERPINI1,
PITX1,
PLAG1,
SLCO1C1,
CPSF2,
POMC,
FEV,
BCAS3,
UQCC1,
ZDHHC7,
ADAP2,
PRKG2,
ADAMTSL3,
ADGRG6,
HACE1,
PTMA,
GATAD1,
PEX2,
ZNF462,
RBBP8,
BCR,
RPS20,
KIF13A,
NCAPG,
POPDC3,
HHIP,
SH3GL3,
COPS7B,
BMP2,
BMP3,
BMP6
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员