KCNJ3 - potassium voltage-gated channel subfamily J member 3-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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3760 KCNJ3

基因描述

Type	Description
Definition	potassium voltage-gated channel subfamily J member 3

研究结论

Date	Results	Publications
2020-11-21 13:14:00	GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A.	31848385
2020-08-29 12:49:00	A constricted opening in Kir channels does not impede potassium conduction.	32541684
2020-02-15 11:52:00	Mutant KCNJ3 and KCNJ5 as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.	30764634
2019-03-02 12:37:00	Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation	30240440
2018-02-24 11:37:00	these data suggest that patients with estrogen receptor positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor	27835900

名称对应

Type	IDs
Synonymous	GIRK1, KGA, KIR3.1
Gene	UniProtKB-ID: KCNJ3_HUMAN, D2XBF0_HUMAN, D2X9V0_HUMAN UniprotKB: P48549, D2XBF0, D2X9V0 UniParc: UPI0001C22631, UPI00017A6C76, UPI000012D899, UPI0001C226A7 EMBL: U39196, AC093633, GU068048, AC061961, AC107060, AK293824, GU074515, BC022495, U50964, GU074516 Ensembl: ENSG00000162989 KO: hsa:3760
Nucleutide sequences	EMBL-CDS: BAG57228.1, AAB53094.1, AAB42176.1, ADB11081.1, AAH22495.1, ADB11082.1, ADB11083.1 Ensembl_TRS: ENST00000544049, ENST00000295101
Protein sequencees	Ensembl_PRO: ENSP00000438410, ENSP00000295101 RefSeq: NP_001247438.1, NP_002230.1, NP_001247437.1, NP_001247439.1
Others	UniRef100: UniRef100_D2X9V0, UniRef100_P48549, UniRef100_D2XBF0 UniRef90: UniRef90_A0A5E4CZL2, UniRef90_D2X9V0, UniRef90_P48549 UniRef50: UniRef50_W5PDS2, UniRef50_P48549, UniRef50_H9GIV0 UniGene: Hs.591606 CCDS: CCDS58733.1, CCDS2200.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
32541684	A constricted opening in Kir channels does not impede potassium conduction. Nat Commun Katrina A Black , Sitong He , Ruitao Jin , David M Miller , Jani R Bolla , Oliver B Clarke , Paul Johnson , Monique Windley , Christopher J Burns , Adam P Hill , Derek Laver , Carol V Robinson , Brian J Smith , Jacqueline M Gulbis	2020-06-15	-
31848385	GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A. Sci Rep Gebhard Schratter , Susanne Scheruebel , Sonja Langthaler , Katja Ester , Brigitte Pelzmann , Nassim Ghaffari-Tabrizi-Wizsy , Simin Rezania , Astrid Gorischek , Dieter Platzer , Klaus Zorn-Pauly , Helmut Ahammer , Andreas Prokesch , Stefanie Stanzer , Trevor T J Devaney , Kurt Schmidt , Stephan W Jahn , Ruth Prassl , Thomas Bauernhofer , Wolfgang Schreibmayer	2019-12-17	-
30764634	Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. Circulation Noriaki Yamada , Yoshihiro Asano , Masashi Fujita , Satoru Yamazaki , Atsushi Inanobe , Norio Matsuura , Hatasu Kobayashi , Seiko Ohno , Yusuke Ebana , Osamu Tsukamoto , Saki Ishino , Ayako Takuwa , Hidetaka Kioka , Toru Yamashita , Norio Hashimoto , Dimitar P Zankov , Akio Shimizu , Masanori Asakura , Hiroshi Asanuma , Hisakazu Kato , Yuya Nishida , Yohei Miyashita , Haruki Shinomiya , Nobu Naiki , Kenshi Hayashi , Takeru Makiyama , Hisakazu Ogita , Katsuyuki Miura , Hirotsugu Ueshima , Issei Komuro , Masakazu Yamagishi , Minoru Horie , Koichi Kawakami , Tetsushi Furukawa , Akio Koizumi , Yoshihisa Kurachi , Yasushi Sakata , Tetsuo Minamino , Masafumi Kitakaze , Seiji Takashima	2019-04-30	-
30240440	Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation. PLoS ONE Michihiro Tateyama , Yoshihiro Kubo	2018-01-01	-
28611215	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown	2017-06-27	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
27835900	KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients. Oncotarget Sarah Kammerer , Armin Sokolowski , Hubert Hackl , Dieter Platzer , Stephan Wenzel Jahn , Amin El-Heliebi , Daniela Schwarzenbacher , Verena Stiegelbauer , Martin Pichler , Simin Rezania , Heidelinde Fiegl , Florentia Peintinger , Peter Regitnig , Gerald Hoefler , Wolfgang Schreibmayer , Thomas Bauernhofer	2016-12-20	-
27519272	Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner. BMC Cancer S Rezania , S Kammerer , C Li , B Steinecker-Frohnwieser , A Gorischek , T T J DeVaney , S Verheyen , C A Passegger , N Ghaffari Tabrizi-Wizsy , H Hackl , D Platzer , A H Zarnani , E Malle , S W Jahn , T Bauernhofer , W Schreibmayer	2016-08-12	-
27074664	The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. Elife Kouki K Touhara , Weiwei Wang , Roderick MacKinnon	2016-04-13	-
25599232	Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery. Pain Dale J Langford , Steven M Paul , Claudia M West , Laura B Dunn , Jon D Levine , Kord M Kober , Marylin J Dodd , Christine Miaskowski , Bradley E Aouizerat	2015-03-01	-

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