NRROS - negative regulator of reactive oxygen species-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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375387 NRROS

基因描述

Type	Description
Definition	negative regulator of reactive oxygen species

研究结论

Date	Results	Publications
2020-05-16 11:46:00	Wild-type and mutant proteins co-localize with latent TGF-beta1 intracellularly.	32197075
2020-03-21 10:37:00	A SNP at the rs6583331 locus 3q29 is associated with the susceptibility of vitiligo in the Chinese Han population. The T allele of the locus within the gene (3q29) was significantly associated with vitiligo (odds ratio = 1.22, 95% confidence interval: 1.10-1.36, p = 0.0001). Association at the genotype level was strong (p = 0.0007).	31644309
2020-03-14 12:22:00	LRRC33 co-localizes and forms complex with latent TGF-beta1 protein on the cell surface and intracellularly in these cells.	31600200
2014-09-13 12:14:00	results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis.	24550525
2013-07-06 10:41:00	LRRC33 represents the first identified LRR-containing protein that plays a critical role in desensitizing Toll-like receptor (TLR)-mediated innate immune responses.	23545260

名称对应

Type	IDs
Synonymous	ELLP3030, GARPL1, LRRC33, UNQ3030
Gene	UniProtKB-ID: LRC33_HUMAN UniprotKB: Q86YC3 UniParc: UPI000000DA7E EMBL: AY358322, BC044233 Ensembl: ENSG00000174004 KO: hsa:375387
Nucleutide sequences	EMBL-CDS: AAQ88688.1, AAH44233.1 Gene_ORFName: UNQ3030/PRO9833 Ensembl_TRS: ENST00000328557
Protein sequencees	Ensembl_PRO: ENSP00000328625 RefSeq: NP_940967.1
Others	UniRef100: UniRef100_Q86YC3 UniRef90: UniRef90_Q86YC3 UniRef50: UniRef50_Q8BMT4 UniGene: Hs.702186 CCDS: CCDS3319.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32197075	Bi-allelic LoF NRROS Variants Impairing Active TGF-Î²1 Delivery Cause a Severe Infantile-Onset Neurodegenerative Condition with Intracranial Calcification. Am J Hum Genet Xiaomin Dong , Natalie B Tan , Katherine B Howell , Sabina Barresi , Jeremy L Freeman , Davide Vecchio , Maria Piccione , Francesca Clementina Radio , Daniel Calame , Shan Zong , Stefanie Eggers , Ingrid E Scheffer , Tiong Y Tan , Nicole J Van Bergen , Marco Tartaglia , John Christodoulou , Susan M White	2020-04-02	-
31644309	Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population. Genet Test Mol Biomarkers Xianfa Tang , Fang Fang , Jingjing Yang , Xiaodong Zheng , Min Fan , Liyun Wang , Anping Zhang	2019-11-01	-
31600200	LRRC33 is a novel binding and potential regulating protein of TGF-Î²1 function in human acute myeloid leukemia cells. PLoS ONE Wenjiang Ma , Yan Qin , Bjoern Chapuy , Chafen Lu	2019-01-01	-
29909984	A Milieu Molecule for TGF-Î² Required for Microglia Function in the Nervous System. Cell Yan Qin , Brian S Garrison , Wenjiang Ma , Rui Wang , Aiping Jiang , Jing Li , Meeta Mistry , Roderick T Bronson , Daria Santoro , Charlotte Franco , Daisy A Robinton , Beth Stevens , Derrick J Rossi , Chafen Lu , Timothy A Springer	2018-06-28	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
24550525	Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. J. Leukoc. Biol. Xiaomin Su , Shiyue Mei , Xue Liang , Shihua Wang , Jingyi Liu , Yuan Zhang , Yue Bao , Yanan Chen , Yongzhe Che , Robert Chunhua Zhao , Zhujun Zhang , Rongcun Yang	2014-07-01	-
23545260	Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-ÎºB activation. Biochem. Biophys. Res. Commun. Jingyi Liu , Zhujun Zhang , Limin Chai , Yongzhe Che , Siping Min , Rongcun Yang	2013-04-26	-
22268729	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. J. Proteome Res. Bin Liu , Ying Zheng , Tong-Dan Wang , Han-Zhang Xu , Li Xia , Jian Zhang , Ying-Li Wu , Guo-Qiang Chen , Li-Shun Wang	2012-03-02	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7

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