| Type | Description |
|---|---|
| Definition | potassium voltage-gated channel subfamily D member 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:35:00 | Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. | 32709127 |
| 2020-10-24 13:58:00 | KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. | 31600170 |
| 2020-03-14 11:43:00 | we utilized the NGS technology to identify two novel KCND3 mutations from two distinct pedigrees with molecularly unassigned SCA. Our clinical observations broaden the genotypic and phenotypic spectrum of SCA19/22 to include cerebellar ataxia, developmental delay, cognitive impairment, myoclonus, and dystonia, thereby emphasizing the significance of KCND3 mutations in a wide range of different neurological disorders. | 31293010 |
| 2019-12-14 10:49:00 | The S248R and R250T mutations of SCN1Bbeta gene caused gain-of-function of Ito by associated with Kv4.3, which maybe underlie the early repolarization syndrome (ERS) phenotype of the probands. | 30160358 |
| 2019-07-20 10:14:00 | The alpha subunit of Ito Kv4.3 can interact with and modify the localization of the alpha subunit of IKr hERG, thus providing potentially novel insights into the molecular mechanism of the malignant ventricular arrhythmia in heart failure. | 29259226 |
| Type | IDs |
|---|---|
| Synonymous | BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22 |
| Gene |
UniProtKB-ID:
KCND3_HUMAN,
A0A024R0C6_HUMAN
UniprotKB:
Q9UK17,
A0A024R0C6
UniParc:
UPI000003050A,
UPI0000030509
EMBL:
AF166009,
AF187964,
BC113475,
AF166011,
AF205857,
CH471122,
AF120491,
AF048712,
AF166010,
BC113477,
AF048713,
AF187963,
AL049557,
AL450997,
AL512665,
AF205856
Ensembl:
ENSG00000171385
KO:
hsa:3752
|
| Nucleutide sequences |
EMBL-CDS:
AAF68177.1,
AAF20925.1,
AAF68178.1,
AAF20924.1,
EAW56511.1,
AAF01045.1,
AAC05121.1,
AAD38898.1,
AAF01044.1,
AAI13476.1,
AAC05122.1,
AAI13478.1,
EAW56512.1
Gene_ORFName:
hCG_40081
Ensembl_TRS:
ENST00000302127,
ENST00000369697,
ENST00000315987
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000306923,
ENSP00000319591,
ENSP00000358711
RefSeq:
NP_004971.2,
XP_011539729.1,
XP_011539728.1,
NP_001365899.1,
XP_006710695.1,
XP_016856734.1,
NP_001365898.1,
XP_016856733.1,
XP_006710692.1,
XP_011539730.1,
XP_006710694.1,
XP_011539727.1,
NP_751948.1
|
| Others |
UniRef100:
UniRef100_Q9UK17,
UniRef100_A0A024R0C6
UniRef90:
UniRef90_Q62897,
UniRef90_Q62897-2
UniRef50:
UniRef50_Q63881,
UniRef50_Q62897-2
UniGene:
Hs.666367
CCDS:
CCDS844.1,
CCDS843.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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