| Type | Description |
|---|---|
| Definition | BRCA1, DNA repair associated |
| Date | Results | Publications |
|---|---|---|
| 2016-02-06 11:31:00 | BRCA1 promotes G2 arrest and cell death by prolonging phosphorylation of Chk1 on serine 345 after DNA damage to sustain arrest. | 26324327 |
| 2015-05-02 12:28:00 | All mutations, regardless of how profound their destabilizing effects, retained some DNA repair activity and partially rescued BRCA1 knockout. | 25748678 |
| 2010-03-15 12:09:00 | BRCA1-CtIP complex plays a role in the nuclease-mediated elimination of oligonucleotides covalently bound to polypeptides from double-strand breaks, thereby facilitating DNA repair. | 20107609 |
| 2010-01-21 00:00:00 | The tumor suppressor BRCA1 tandem C-terminal BRCT2 and BRCT3 domains of Mcph1 are necessary for the formation of ionizing radiation-induced nuclear foci, while the N-terminal BRCT1 is required for centrosomal localization in irradiated cells. | 17599047 |
| 2010-01-21 00:00:00 | The function of CtIP in homologous recombination, but not MMEJ, is dependent on the phosphorylation of serine residue 327 and recruitment of BRCA1 | 19357644 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q90Z51_CHICK
UniprotKB:
Q90Z51
UniParc:
UPI00000FD19C
EMBL:
AF355273
KO:
gga:373983
|
| Nucleutide sequences |
EMBL-CDS:
AAK83825.1
|
| Protein sequencees |
RefSeq:
NP_989500.1,
XP_015155048.1,
XP_015155047.1,
XP_024999709.1,
XP_015155049.1,
XP_015155051.1
|
| Others |
UniRef100:
UniRef100_Q90Z51
UniRef90:
UniRef90_F1N8I5
UniRef50:
UniRef50_F1N8I5
UniGene:
Gga.4493
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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