| Type | Description |
|---|---|
| Definition | DND microRNA-mediated repression inhibitor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:24:00 | MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1. | 32521898 |
| 2020-03-07 10:30:00 | overexpression of DND1 could rescue the tumor suppressive effects of miR-24, indicating direct involvement of DND1 in the miR-24 mediated inhibitory effects on SW48 cell proliferation. The miR-24 acts as a tumor suppressor and may prove essential in the treatment of colorectal cancer (CRC). | 31646794 |
| 2018-04-14 11:24:00 | Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. | 28593479 |
| 2017-02-18 10:24:00 | Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. | 28191469 |
| 2016-06-28 10:18:00 | RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation | 26740055 |
| Type | IDs |
|---|---|
| Synonymous | RBMS4 |
| Gene |
UniProtKB-ID:
DND1_HUMAN
UniprotKB:
Q8IYX4
UniParc:
UPI00000741C8
EMBL:
BC033496,
AY321065
Ensembl:
ENSG00000256453
KO:
hsa:373863
|
| Nucleutide sequences |
EMBL-CDS:
AAH33496.1,
AAQ63635.1
Ensembl_TRS:
ENST00000542735
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000445366
RefSeq:
NP_919225.1
|
| Others |
UniRef100:
UniRef100_Q8IYX4
UniRef90:
UniRef90_Q8IYX4
UniRef50:
UniRef50_Q8IYX4
UniGene:
Hs.591262
CCDS:
CCDS4236.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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