| Type | Description |
|---|---|
| Definition | jagged canonical Notch ligand 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 11:19:00 | Results showed that Jagged2 was highly expressed in paclitaxel-resistant triple negative breast cancer (TNBC) tissues and cells. Jagged2 expression was found to be associated with cancer stem cell (CSC) properties of TNBC cells. Jagged2 maintains CSC properties of TNBC cells and paclitaxel resistance via regulating microRNA-200. | 30280784 |
| 2020-01-18 11:18:00 | The CT genotype of rs741859 could significantly reduce the risk for NSCLP to 65% (P< 0.05) and the risk for cleft lip with or without cleft palate (CL/P) to 62% (P< 0.05). | 31922603 |
| 2019-10-19 12:16:00 | CD14(+) monocytes serve as Langerhans cell histiocytosis (LCH) cell precursor and JAG2-mediated activation of the Notch signaling pathway initiates a differentiation of monocytes toward LCH cells. | 30296338 |
| 2019-06-08 10:54:00 | Long noncoding RNA (lncRNA) ENST00000455974 was significantly associated with TNM stage and distant metastasis in patients with DNA mismatch repair-proficient colon cancer. ENST00000455974 was gradually increased across the colonic normal-adenoma-carcinoma-metastasis sequence. ENST00000455974 was mainly located in the nucleus of colon cancer cells and it promoted growth and metastasis through up-regulating JAG2. | 30473216 |
| 2018-01-27 10:08:00 | In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). | 26151095 |
| Type | IDs |
|---|---|
| Synonymous | HJ2, SER2 |
| Gene |
UniProtKB-ID:
JAG2_HUMAN
UniprotKB:
Q9Y219
UniParc:
UPI0000167BD5,
UPI0000160680
EMBL:
AF111170,
AF029778,
AF029779,
Y14330,
AF003521,
AF020201
Ensembl:
ENSG00000184916
KO:
hsa:3714
|
| Nucleutide sequences |
EMBL-CDS:
AAD15562.1,
AAB84215.1,
AAB61285.1,
AAB71189.1,
CAA74706.1,
AAB84216.1
Ensembl_TRS:
ENST00000331782,
ENST00000347004
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000328566,
ENSP00000328169
RefSeq:
NP_002217.3,
NP_660142.1
|
| Others |
UniRef100:
UniRef100_Q9Y219
UniRef90:
UniRef90_Q9Y219
UniRef50:
UniRef50_Q9QYE5
UniGene:
Hs.433445
CCDS:
CCDS9998.1,
CCDS9999.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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