| Type | Description |
|---|---|
| Definition | DNA topoisomerase type I |
| Date | Results | Publications |
|---|---|---|
| 2017-07-29 10:44:00 | Data suggest that the N-terminal domain is important for binding of DNA topoisomerase IB (TopIB) to duplex DNA; the N-terminal domain (amino acids 1-80) appears to engage the major groove on the DNA face opposite the scissile phosphodiester. | 28570045 |
| 2013-03-30 12:17:00 | Changing Lys167 to cysteine crippled the DNA cleavage and religation transesterification steps (k(cl) = 4.3 x 10(-4) s(-1); k(rel) = 9 x 10(-4) s(-1)). | 23317114 |
| 2011-12-24 10:04:00 | P-thiophenylalanine was incorporated into the enzyme active site. The modification, which resulted in replacement of the nucleophilic tyrosine OH group with SH, retained DNA topoisomerase activity and did not alter the DNA cleavage site. | 21942719 |
| 2010-05-31 11:37:00 | mechanism where vTopo oscillates between an open state where the downstream DNA segment does not interact with the enzyme and a closed state where catalytically important contacts are formed with this region. | 20187656 |
| 2010-01-21 00:00:00 | The Phe215 side chain makes van der Waals contacts to Ile98, Met121 and Phe101, which we propose stabilize a three helix bundle and promote clamp closure | 17059840 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TOP1_VACCA,
TOP1_VACCW,
Q49QF8_9POXV
UniprotKB:
Q76ZS7,
P68698,
Q49QF8
UniParc:
UPI000000001C
EMBL:
KJ125439,
DQ121394,
MK314710,
MH341446,
DQ377945,
AY243312,
KX781953,
KX061501,
MK314713,
KC207810,
M13209,
JX489136,
JN654981,
MK314712,
JN654983,
JX489137,
U94848,
MH341447,
AY678275,
MK336431,
KP233807,
KC207811,
KM044310,
KM044309,
AY603355,
MG663594,
JX489135,
MH341445,
L13447,
KC201194,
JN654978,
MK314711,
AY678277,
MN369532
KO:
vg:3707560
|
| Nucleutide sequences |
EMBL-CDS:
AAB96509.1,
AAT10494.1,
AAB59842.1,
AAA02841.1,
AAO89383.1,
AXN56159.1,
AIX99223.1,
AGK06786.1,
AGJ91546.1,
AEY73862.1,
QCI57516.1,
AXN56641.1,
AGJ91273.1,
AAW23516.1,
AXN56400.1,
AGB75825.1,
AAW23798.1,
QCI57122.1,
QCI57713.1,
AIZ72853.1,
ABD52571.1,
AIX99428.1,
AGJ91816.1,
AEY74343.1,
QCI57320.1,
AIX99021.1,
AUO38403.1,
AND73938.1,
QEG58912.1,
AQY54878.1,
AEY73150.1,
AGK06573.1,
ABD57634.1,
QKE61245.1
Gene_ORFName:
H6R,
VAC_DPP11_115,
VAC_TKT3_094,
List100,
44.1rMVA_092,
51.1rMVA_117,
47.1rMVA_096,
VACV_TT9_125,
VAC_TP5_109,
VACV_100,
LIVPclone14_112,
VAC_DPP15_115,
VACV_TT10_125,
VAC_TP3_109,
m8123R,
44/47.1_rMVA_097,
mO123R,
VAC_IHDW1_106,
51.2rMVA_103,
VAC_TKT4_094,
VAC_DPP17_115,
VACV_TT8_125
|
| Protein sequencees |
RefSeq:
YP_232986.1
|
| Others |
UniRef100:
UniRef100_Q76ZS7
UniRef90:
UniRef90_P32989
UniRef50:
UniRef50_P32989
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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