| Type | Description |
|---|---|
| Definition | inositol-trisphosphate 3-kinase B |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:28:00 | Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. | 31987846 |
| 2020-04-18 10:48:00 | study also suggests a distinctive signaling function of IP4 that regulates NOX4. Furthermore, pharmaceutical inhibition of ITPKB displayed synergistic attenuation of tumor growth with cisplatin, suggesting ITPKB as a promising synthetic lethal target for cancer therapeutic intervention to overcome cisplatin resistance. | 31081803 |
| 2019-04-06 10:16:00 | ITPKB does not affect the cellular actin structure and does not suppress dissemination of human lung cancer cells in mice. | 29871874 |
| 2017-12-02 12:37:00 | miR-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). Therefore, the results of the present study demonstrated that miR-140-5p mediated drug-resistance in osteosarcoma cells by inducing autophagy. | 27582507 |
| 2017-09-30 14:16:00 | The authors confirm downregulation of miR-132 and upregulation of ITPKB in three distinct human Alzheimer's disease patient cohorts. | 27485122 |
| Type | IDs |
|---|---|
| Synonymous | IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37 |
| Gene |
UniProtKB-ID:
IP3KB_HUMAN,
B2R9J0_HUMAN
UniprotKB:
P27987,
B2R9J0
UniParc:
UPI00017506BC,
UPI00002040B8,
UPI000013D92B
EMBL:
AJ242780,
X57206,
Y18024,
BC015009,
AK313801,
AL365444
Ensembl:
ENSG00000143772
KO:
hsa:3707
|
| Nucleutide sequences |
EMBL-CDS:
CAC40650.1,
CAB65055.3,
AAH15009.1,
CAA40491.1,
BAG36537.1
Ensembl_TRS:
ENST00000272117,
ENST00000429204,
ENST00000366784
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000272117,
ENSP00000355748,
ENSP00000411152
RefSeq:
NP_002212.3,
NP_001375333.1,
XP_016856700.1
|
| Others |
UniRef100:
UniRef100_P27987,
UniRef100_B2R9J0
UniRef90:
UniRef90_Q2TU82,
UniRef90_P27987
UniRef50:
UniRef50_Q2TU82,
UniRef50_P27987
UniGene:
Hs.528087,
Hs.659396
CCDS:
CCDS1555.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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